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Table 4 Summary of key findings, outcomes and strength of evidence

From: A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments

Outcome Study designs/
No. Studies
Findings and Direction of Effect GRAD E[21]
1. Uptake of HCV treatment RCT – 2
Cohort – 3
Observational – 5
Two RCTs assessed as having low risk of bias reported a positive effect on uptake with precision and a consistent positive direction of effect. One cohort study assessed as having medium-grade study limitations also reported a positive effect on uptake. Medium
2. Completion of Treatment Cohort - 1
Observational - 2
One cohort study with medium study limitations reported a positive direction of effect on uptake. Low
3. Sustained Viral Response at 12 weeks (%)(SVR12) RCT −2
Cohort - 4
Observational - 11
Two RCTs assessed as having low risk of bias reported a positive effect on SVR but were imprecise in the estimate of effect size. Four cohort studies and 11 observational studies with over 10,000 participants all reported a consistent positive direction of effect, but with significant study limitations. Medium