Opposite trends in hospitalization and mortality after implementation of a chronic care model-based regional program for the management of patients with heart failure in primary care

Table 3 Event-free survival analysis

	Hazard ratio	95% CI	P value
CCM status	1.35	1.19-1.52	< 0.0001
Age class^a
75-85	1.40	1.21-1.63	< 0.0001
> 85	1.59	1.33-1.89	< 0.0001
Female gender	0.96	0.85-1.09	0.51
Charlson index	1.16	1.07-1.26	< 0.0001
Treatment at enrolment
ACE-inhibitors or ARBs	1.09	0.90-1.31	0.38
Beta-blockers	1.24	1.09-1.41	0.0010
Diuretics	2.38	1.87-3.03	< 0.0001
Geographic area	1.00	0.97-1.03	0.99
Previous HF hospitalization	1.11	0.99-1.25	0.069

Predictors of hospitalization in the overall study population, as identified by multivariable Cox regression analysis. ACE angiotensin converting enzyme, ARBs angiotensin receptor blockers, CCM chronic care model, CI confidence interval
^aHazard ratios calculated vs age < 75 years as a reference

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