From: Predictive performance of comorbidity measures in administrative databases for diabetes cohorts
 | Cohort 1a(n= 29,058) | Cohort 2 (n= 41,925) | ||||||
---|---|---|---|---|---|---|---|---|
Model (df)b | c-statisticc (95% CI) | ∆c d (%) | Brier score | LRTe | c-statisticc (95% CI) | ∆c(%) | Brier score | LRTe |
AMI | ||||||||
Base (7) | 0.66 (0.64, 0.68) | . | 0.02 | . | 0.68 (0.66, 0.70) | . | 0.02 | . |
# diagnoses (10) | 0.67 (0.65, 0.69) | 0.01 (1.37) | 0.02 | 21.1* | 0.68 (0.67, 0.71)* | <0.01 (1.47) | 0.02 | 32.1* |
Charlson (10) | 0.67 (0.65, 0.69) | 0.01 (1.52) | 0.02 | 21.5* | 0.69 (0.67, 0.71)* | 0.01 (1.92) | 0.02 | 37.3* |
Elixhauser (35) | 0.68 (0.66, 0.69)* | 0.02 (2.43) | 0.02 | 44.2* | 0.70 (0.68, 0.72)* | 0.02 (2.95) | 0.02 | 62.5* |
# drugs (10) | 0.68 (0.66, 0.69)* | 0.02 (2.43) | 0.02 | 36.0* | 0.68 (0.66, 0.70) | <0.01 (0.88) | 0.02 | 24.1* |
CDS (11) | 0.67 (0.65, 0.69)* | 0.01 (2.28) | 0.02 | 32.8* | 0.68 (0.66, 0.70) | <0.01 (0.29) | 0.02 | 6.1 |
Stroke | ||||||||
Base (7) | 0.70 (0.68, 0.72) | . | 0.02 | . | 0.71 (0.69, 0.72) | . | 0.01 | . |
# diagnoses (10) | 0.71 (0.70, 0.73) | 0.01 (1.57) | 0.02 | 37.8* | 0.71 (0.69, 0.73) | <0.01 (0.85) | 0.01 | 18.9* |
Charlson (10) | 0.72 (0.70, 0.73) | 0.02 (1.85) | 0.02 | 44.3* | 0.71 (0.69, 0.73) | <0.01 (0.85) | 0.01 | 17.2* |
Elixhauser (35) | 0.72 (0.70, 0.74)* | 0.02 (2.56) | 0.02 | 45.4* | 0.71 (0.69, 0.73) | <0.01 (0.85) | 0.01 | 20.6 |
# drugs (10) | 0.71 (0.69, 0.73) | 0.01 (0.85) | 0.02 | 19.5* | 0.71 (0.70, 0.73) | <0.01 (0.99) | 0.01 | 24.2* |
CDS (11) | 0.71 (0.69, 0.73) | 0.01 (1.28) | 0.02 | 33.7* | 0.71 (0.70, 0.73) | <0.01 (0.99) | 0.01 | 21.2* |
LEA | ||||||||
Base (7) | 0.65 (0.62, 0.68) | . | 0.01 | . | 0.68 (0.65, 0.70) | . | 0.01 | . |
# diagnoses (10) | 0.71 (0.69, 0.74)* | 0.06 (10.36) | 0.01 | 77.4* | 0.74 (0.72, 0.77)* | 0.06 (9.75) | 0.01 | 128.7* |
Charlson (10) | 0.74 (0.71, 0.77)* | 0.09 (14.06) | 0.01 | 128.4* | 0.76 (0.74, 0.79)* | 0.08 (12.70) | 0.01 | 201.7* |
Elixhauser (35) | 0.78 (0.75, 0.81)* | 0.13 (20.71) | 0.01 | 305.6* | 0.79 (0.76, 0.82)* | 0.11 (16.69) | 0.01 | 372.8* |
# drugs (10) | 0.70 (0.67, 0.72)* | 0.05 (7.42) | 0.01 | 53.0* | 0.74 (0.72, 0.76)* | 0.06 (9.31) | 0.01 | 110.2* |
CDS (11) | 0.69 (0.66, 0.72)* | 0.04 (6.34) | 0.01 | 42.4* | 0.72 (0.70, 0.75)* | 0.04 (6.65) | 0.01 | 74.5* |
ESRD | ||||||||
Base (7) | 0.67 (0.63, 0.72) | . | <0.01 | . | 0.65 (0.61, 0.69) | . | <0.01 | . |
# diagnoses (10) | 0.74 (0.70, 0.79)* | 0.07 (10.73) | <0.01 | 49.0* | 0.77 (0.73, 0.80)* | 0.12 (18.52) | <0.01 | 128.0* |
Charlson (10) | 0.80 (0.76, 0.84)* | 0.13 (19.08) | <0.01 | 138.6* | 0.82 (0.79, 0.86)* | 0.17 (27.01) | <0.01 | 276.6* |
Elixhauser (35) | 0.84 (0.80, 0.89)* | 0.17 (25.78) | <0.01 | 328.6* | 0.87 (0.84, 0.90)* | 0.22 (34.41) | <0.01 | 555.1* |
# drugs (10) | 0.73 (0.69, 0.76)* | 0.06 (8.20) | <0.01 | 36.6* | 0.71 (0.68, 0.75)* | 0.06 (9.88) | <0.01 | 50.2* |
CDS (11) | 0.75 (0.71, 0.79)* | 0.08 (12.07) | <0.01 | 61.3* | 0.72 (0.68, 0.76)* | 0.07 (11.11) | <0.01 | 55.3* |
Hospitalization, any reason | ||||||||
Base (7) | 0.63 (0.62, 0.64) | . | 0.24 | . | 0.63 (0.62, 0.63) | . | 0.24 | . |
# diagnoses (10) | 0.70 (0.69, 0.71)* | 0.07 (11.13) | 0.22 | 2115.1* | 0.70 (0.69, 0.70)* | 0.07 (11.31) | 0.22 | 3101.3* |
Charlson (10) | 0.68 (0.67, 0.69)* | 0.05 (8.11) | 0.23 | 1424.1* | 0.67 (0.67, 0.68)* | 0.04 (7.32) | 0.23 | 1794.8* |
Elixhauser (35) | 0.69 (0.68, 0.69)* | 0.06 (9.06) | 0.22 | 1663.7* | 0.68 (0.68, 0.69)* | 0.05 (8.60) | 0.23 | 2165.5* |
# drugs (10) | 0.66 (0.66, 0.67)* | 0.03 (5.09) | 0.23 | 823.1* | 0.65 (0.65, 0.66)* | 0.02 (3.98) | 0.23 | 996.2* |
CDS (11) | 0.65 (0.64, 0.66)* | 0.02 (3.50) | 0.23 | 539.2* | 0.64 (0.64, 0.65)* | 0.01 (2.23) | 0.24 | 503.0* |
Hospitalization, diabetes | ||||||||
Base (7) | 0.60 (0.59, 0.61) | . | 0.18 | . | 0.59 (0.59, 0.60) | . | 0.15 | . |
# diagnoses (10) | 0.65 (0.65, 0.66)* | 0.05 (8.65) | 0.18 | 889.9* | 0.66 (0.65, 0.66)* | 0.07 (10.83) | 0.15 | 1251.0* |
Charlson (10) | 0.66 (0.65, 0.67)* | 0.06 (9.65) | 0.17 | 1194.1* | 0.65 (0.64, 0.66)* | 0.06 (9.98) | 0.15 | 1141.8* |
Elixhauser (35) | 0.67 (0.66, 0.68)* | 0.07 (11.65) | 0.17 | 1554.3* | 0.66 (0.66, 0.67)* | 0.07 (12.35) | 0.15 | 1715.9* |
# drugs (10) | 0.64 (0.63, 0.64)* | 0.04 (5.66) | 0.18 | 524.5* | 0.63 (0.62, 0.63)* | 0.04 (6.09) | 0.15 | 633.9* |
CDS (11) | 0.63 (0.62, 0.63)* | 0.03 (4.16) | 0.18 | 365.1* | 0.62 (0.61, 0.63)* | 0.03 (4.57) | 0.15 | 397.7* |
Death | ||||||||
Base (7) | 0.77 (0.76, 0.78) | . | 0.08 | . | 0.79 (0.78, 0.79) | . | 0.07 | . |
# diagnoses (10) | 0.79 (0.78, 0.80)* | 0.02 (3.39) | 0.08 | 499.4* | 0.80 (0.80, 0.81)* | 0.01 (2.16) | 0.07 | 475.1* |
Charlson (10) | 0.82 (0.81, 0.82)* | 0.05 (6.53) | 0.07 | 1014.0* | 0.82 (0.82, 0.83)* | 0.03 (4.57) | 0.07 | 1018.0* |
Elixhauser (35) | 0.83 (0.82, 0.83)* | 0.06 (7.96) | 0.07 | 1379.9* | 0.84 (0.83, 0.84)* | 0.05 (6.10) | 0.06 | 1618.7* |
# drugs (10) | 0.79 (0.78, 0.80)* | 0.02 (2.74) | 0.08 | 429.1* | 0.80 (0.79, 0.81)* | 0.01 (1.78) | 0.07 | 401.4* |
CDS (11) | 0.78 (0.77, 0.79)* | 0.01 (1.96) | 0.08 | 306.1* | 0.79 (0.79, 0.80)* | <0.01 (0.89) | 0.07 | 216.9* |