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Design of a care pathway for pharmacy-based PrEP delivery in Kenya: results from a collaborative stakeholder consultation

Abstract

Introduction

In Kenya, pre-exposure prophylaxis (PrEP) for HIV prevention is almost exclusively delivered at HIV clinics. Developing novel PrEP delivery models is important for increasing the reach of PrEP. Delivery of PrEP through pharmacies is one approach utilized in the US to improve accessibility. Retail pharmacies are commonly used as a first-line access point for medical care in Kenya, but have not been utilized for PrEP delivery. We conducted a collaborative consultative meeting of stakeholders to develop a care pathway for pharmacy-based PrEP delivery in Kenya.

Methods

In January 2020, we held a one-day meeting in Nairobi with 36 stakeholders from PrEP regulatory, professional, healthcare service delivery, civil society, and research organizations. Attendees reviewed a theory of change model, results from formative qualitative research with pharmacy providers and clients, and anticipated core components of pharmacy-based PrEP delivery: counseling, HIV testing, prescribing, and dispensing. Stakeholders participated in small and large group discussions to identify potential challenges and solutions. We synthesized the key findings from these discussions.

Results

Stakeholders were enthusiastic about a model for pharmacy-based PrEP delivery. Potential challenges identified included insufficient pharmacy provider knowledge and skills, regulatory hurdles to providing affordable HIV testing at pharmacies, and undefined pathways for PrEP procurement. Potential solutions identified included having pharmacy providers complete the Kenya Ministry of Health-approved PrEP training, use of a PrEP prescribing checklist with remote clinician oversight and provider-assisted HIV self-testing, and having the government provide PrEP and HIV self-testing kits to pharmacies during a pilot test. A care pathway was developed over the course of the meeting.

Conclusions

PrEP delivery stakeholders in Kenya were strongly supportive of developing and testing a model for pharmacy-based PrEP delivery to increase PrEP access. We collaboratively developed a care pathway for pilot testing that has the potential to expand PrEP delivery options in Kenya and other similar settings.

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Introduction

Maximizing access and reaching at-risk populations are key priorities for optimizing the public health impact of pre-exposure prophylaxis (PrEP) for HIV prevention [1, 2]. PrEP is highly effective and safe when taken as prescribed [3,4,5,6]. In sub-Saharan Africa, PrEP is being added to an already-stretched public health infrastructure, and the ability of the health systems to maximize PrEP access will necessitate finding novel delivery strategies [7]. In feasibility evaluations of PrEP in sub-Saharan Africa, major barriers to clinic-based PrEP delivery include stigma, long waiting times, the costs of staffing, and healthcare providers’ unfamiliarity with delivering prevention interventions [8,9,10].

In Kenya and many other resource-constrained countries, retail pharmacies fill an important gap in the health care system, providing access to treatment of urgent conditions (e.g., evaluation and medication for sexually transmitted infections [STIs]), monitoring of chronic conditions (e.g., blood pressure and diabetes), point-of-care testing (e.g., for malaria and HIV), and preventative care (e.g., contraception) [11,12,13,14,15,16]. Pharmacy-based care has many attributes that may be desirable for potential PrEP users, including convenience (as pharmacies outnumber clinics and have shorter waiting times), anonymity (compared to seeking PrEP at a public HIV care center), and engagement (which may be greater for a preventative service at a pharmacy than at a clinic that prioritizes treating patients with existing health conditions) [17,18,19]. Pharmacies can offer free, subsidized, or fully fee-for-service care, and paying for a service could result in greater sustained consumer engagement. The core components of PrEP – including HIV testing, adherence and risk reduction counseling, assessment of side effects, and provision of refills [20, 21] – are all within the scope of practice for pharmacy professionals [22, 23]. In the US, one model has demonstrated that PrEP can be provided completely by pharmacists, with oversight by a remote physician [24, 25].

To develop a model for pharmacy-based PrEP delivery for pilot testing in Kenya, we convened a meeting of stakeholders with diverse professional backgrounds and roles in PrEP delivery to collaboratively design a pathway that aligns with Kenya’s national PrEP and HIV prevention guidelines [21, 26]. In implementation science, the process of moving from formative research to the development of a model for testing is seldom detailed in the literature. This paper aims to document this process and present a collaboratively-developed model for pharmacy-based PrEP delivery that will be refined and tested before being scaled in Kenya and other similar settings.

Methods

Setting

In Kenya, PrEP is currently being delivered at most health facilities. In 2019, nearly 2000 public HIV clinics in Kenya were offering PrEP and approximately 63,000 individuals were on PrEP [27], with over half of them at public HIV clinics [28]. In 2019, there were 6375 registered pharmacies in Kenya: 5239 retail, 437 wholesale, and 799 hospital pharmacies [29]. The retail pharmacies we are focusing on in this study are primarily privately owned and staffed by pharmaceutical technologists. The Kenyan Ministry of Health (MOH) recently collaborated with private retail pharmacies to deliver HIV self-tests and facilitate linkage to care support and thus has established relationships with retail pharmacies across the country [30, 31].

Stakeholder selection

We convened a consultation of individuals from different regulatory, professional, healthcare service delivery, civil society, and research organizations in Kenya (Appendix I). We included individuals from diverse professional backgrounds who had different roles in PrEP delivery so that we could develop the most comprehensive care pathway that included all the appropriate details for pharmacy-based PrEP delivery (in regards to testing, counseling, and record keeping), fit within existing Kenya national PrEP guidelines, and was acceptable to both implementers and regulators.

Meeting activities

The one-day stakeholder meeting in Nairobi, Kenya featured presentations from stakeholders and researchers, as well as small and large group discussions. Two facilitators (EB, KN) with expertise in PrEP and implementation research oversaw the meeting. The meeting — including group discussions — was audio-recorded for purposes of note-taking.

Representatives from Kenya’s National AIDS & STI Control Program (NASCOP) and Pharmacy & Poisons Board (PPB) opened the meeting with presentations on the role of PrEP in Kenya’s national HIV prevention plan. Next, members of our research team presented a theory of change for how pharmacy-based PrEP delivery may overcome barriers to PrEP access and delivery and outlined the anticipated core components of pharmacy-based PrEP delivery in Kenya (i.e., counseling, HIV testing, prescribing, dispensing, oversight/referral). A mock care pathway for the delivery of these components was presented, based on a pharmacy-based PrEP delivery model ongoing in the US [24].

Following presentations, stakeholders were divided into three small groups to discuss the potential for pharmacy-based PrEP delivery to address the barriers to PrEP access and delivery presented in the theory of change model. Stakeholders were grouped purposefully to equally distribute different perspectives (e.g., pharmacy professionals, laboratory technologists, clinicians, researchers, governmental officials) across the groups. To help guide discussion, each group received worksheets (organized by the anticipated core components of pharmacy-based PrEP delivery) on current practices and potential barriers to pharmacy-based PrEP delivery (Appendix II) and potential solutions and regulatory requirements needed to address identified barriers (Appendix III). After completion of each worksheet, the small groups shared their discussion points with the larger group. After completion of the small and large group discussions, the facilitators summarized the key points that emerged during the discussions and presented an updated pharmacy-based PrEP delivery care pathway, which was interrogated by group consensus for its various proposed components.

We received ethical approval to conduct formative research, including engagement with stakeholders during a one-day meeting, from institutional review boards at the Kenya Medical Research Institute and University of Washington.

Results

Introductory statements

Both NASCOP and PPB gave introductory statements that were strongly supportive of developing models for pharmacy-based PrEP delivery in Kenya. The organizations acknowledged the limitations of clinic-based PrEP delivery and stressed the need for evidence that alternative models of PrEP delivery work. Both organizations emphasized their commitment to working with researchers to support the development of such models and outlined key questions related to the development of pharmacy-based PrEP delivery. Their questions centered around the minimum criteria pharmacies should meet to deliver PrEP, capacity-building needs among pharmacy providers,acceptable modalities of PrEP delivery at pharmacies (e.g., initiation at pharmacies and continuation at HIV clinics, initiation at HIV clinics and refills at pharmacies, etc.), data for tracking pharmacy-based PrEP delivery, and the role of NASCOP and PPB in the process.

Theory of change & anticipated core components

In our theory of change model, Fig. 1, pharmacy-based PrEP delivery may overcome both patient-level and provider-level barriers to clinic-based PrEP delivery. Specifically, we anticipate that relative to clinic-based PrEP delivery, pharmacy-based PrEP delivery will increase patients’ privacy because individuals often come to pharmacies for a variety of reasons, convenience because retail pharmacies outnumber HIV clinics and have longer opening hours, and choice because individuals at HIV risk can select their preferred location for PrEP care. Additionally, we anticipate that pharmacy-based PrEP delivery will decrease the time patients spend waiting for PrEP care, the cost of traveling to a location where PrEP can be accessed, and the stigma associated with PrEP use (which is often amplified when individuals have to visit an HIV clinic for PrEP care). Pharmacy-based PrEP delivery may also decrease the salary costs of PrEP providers because retail pharmacy providers (i.e., pharmaceutical technologists) often make less than clinicians, decrease overcrowding at HIV clinics by moving care for healthy individuals to other settings, and increase the number of health providers that are familiar with and can provide PrEP care. Overall, we anticipate this novel model of PrEP delivery will increase the reach of PrEP to individuals at HIV risk who would never visit an HIV clinic for PrEP care, the total number of individuals initiating PrEP, and PrEP continuation (i.e., retention and adherence) among those using PrEP, ultimately decreasing overall HIV transmission in Kenya.

Fig. 1
figure 1

Theory of change for how pharmacy-based PrEP delivery may overcome barriers to clinic-based PrEP delivery in Kenya

Following presentation of our theory of change model, we presented the anticipated core components of pharmacy-based PrEP initiation and refills: counseling, HIV testing, prescribing, and dispending, with oversight by a remote clinician and referral to a health facility when needed, Fig. 2.

Fig. 2
figure 2

Anticipated core components of pharmacy-based PrEP delivery in Kenya. Source: Developed by the authors of this manuscript in collaboration with the Stakeholders for Pharmacy-based PrEP Delivery in Kenya (full permissions for image use received)

Challenges and solutions

During small and large group discussions, stakeholders identified a number of challenges and solutions, both for the pilot study of pharmacy-based PrEP delivery and for larger scale-up in Kenya. Findings from these discussions are summarized in Table 1. We subdivided the proposed solutions into short-term solutions that can be incorporated into the pilot study and long-term solutions that are geared more toward the future scale up of pharmacy-based PrEP delivery.

Table 1 Potential challenges and solutions to pharmacy-based PrEP delivery

Anticipated challenges primarily centered on pharmacy provider knowledge and skills to deliver PrEP. To ensure that the pharmacy providers in the pilot study have sufficient skills to deliver PrEP, stakeholders suggested training using existing NASCOP PrEP materials and guidelines. For future pharmacy PrEP scale up, stakeholders suggested that the Kenya MOH establish training requirements specifically for pharmacy providers and that NASCOP PrEP training materials be customized to fit the retail pharmacy setting. Stakeholders agreed that the pilot study should have pharmacy providers use a stakeholder-approved checklist to guide PrEP prescribing and a remote clinician available for consultation (via both the phone and WhatsApp). If this model is successful in a pilot setting, stakeholders expressed interest in testing this model at scale (potentially by pairing retail pharmacies with specific health facilities that can provide oversight, referral, and supply of PrEP medication) and, in the future, having PPB consider rescheduling PrEP medications so that is available without a prescription (pending scale-up findings).

Other anticipated challenges to pharmacy-based PrEP delivery included lack of guidelines for PrEP delivery in pharmacies, including whether and how pharmacies can advertise PrEP, test for HIV, procure and price PrEP, and document PrEP delivery. Stakeholders noted that, currently in Kenya, the PPB does not allow retail pharmacies to publicly advertise name-brand medicines. To attract PrEP clients during the pilot study, stakeholders advocated for pilot pharmacy providers to use word-of-mouth referral, offer PrEP to clients seeking services indicative of HIV risk behavior (e.g., emergency contraception, STI treatment), and obtain permission to display PrEP posters within the confines of the pharmacy. Stakeholders also suggested that, for future pharmacy-based PrEP scale-up, the PPB could revise pharmacy advertising restrictions to include a PrEP exemption, the MOH could implement a national awareness campaign, and NASCOP could create standard PrEP promotional materials for pharmacies.

With respect to HIV testing, stakeholders noted that retail pharmacies are not currently allowed to sell or perform rapid HIV tests but that they are allowed to sell and assist clients with HIV self-testing. For the pilot study, stakeholders felt that only provider-assisted HIV self-testing should be permissible, but that long term solutions for pharmacy-based PrEP scale-up could include developing MOH guidelines for the delivery of rapid HIV testing at pharmacies (including modifying permissions as to who can conduct rapid HIV tests).

With respect to PrEP procurement and pricing, NASCOP and MOH representatives committed to providing the PrEP drugs and HIV self-tests for free to the pharmacies in the pilot study and suggested that pilot pharmacies acquire their PrEP and HIV self-tests through nearby health facilities so that this inventory can be tracked using those facilities’ Master Facility List (MFL) codes. The cost of PrEP to pilot study participants would, therefore, be just a service fee for counseling, and dispensing, but not for the HIV self-test or PrEP drug itself. When asked how PrEP procurement and pricing might be handled in a scale-up situation, stakeholders felt that pharmacy providers could work with non-branded drug manufacturers to procure PrEP and HIV tests, or the MOH could consider giving retail pharmacies their own MFL codes for direct procurement through the Kenya Medical Supplies Agency (KEMSA).

Care pathway for pharmacy-based PrEP delivery

Based on stakeholder feedback and consensus, we revised and finalized the care pathway for pharmacy-based PrEP delivery to pilot test, Fig. 3. We organized this pathway using a PrEP prescribing checklist (Table 2, more detailed form in Appendix III), which includes HIV risk assessment (using the MOH-approved Rapid Assessment Screening Tool), counseling (on HIV risk reduction and PrEP adherence), clinical safety assessment (including screening for HIV symptoms, disease history, and potential PrEP side effects), HIV testing, and PrEP dispensing. This care pathway for pharmacy-based PrEP delivery is designed only for healthy individuals at HIV risk with low likelihood of any drug contraindications. Thus, is it important that pharmacy providers delivering PrEP are trained on approaches to screen potential and continuing PrEP clients for pre-existing (e.g., diabetes, kidney disease) or emerging (e.g., pregnancy, side effects associated with PrEP use) health conditions that might impact safe PrEP use (using the described checklist) and refer those with any identified conditions to a public HIV clinic for continued PrEP care. If a pharmacy PrEP provider has any concerns or questions regarding the health or eligibility of a (potential) PrEP client, he or she can consult a remote clinician via phone or SMS.

Fig. 3
figure 3

Proposed care pathway for pharmacy-based PrEP delivery pilot testing. Source: Developed by the authors of this manuscript in collaboration with the Stakeholders for Pharmacy-based PrEP Delivery in Kenya (full permissions for image use received)

Table 2 Prescribing checklist for pharmacy-based PrEP delivery

Discussion

This collaborative meeting, including a wide cross-section of stakeholders, aimed to spearhead the first national effort to create a formal pathway for pharmacy-based PrEP delivery that bridges the public and private sectors [26, 28]. This stakeholder meeting represents an important initial step by establishing consensus around a pharmacy-based PrEP delivery model to pilot test and identifying considerations for future scale-up, in Kenya and similar settings. If it can be implemented successfully, Kenya’s model for pharmacy-based PrEP delivery could trail blaze a path for other countries in sub-Saharan Africa, thus providing a template for other ministries of health to adapt. Here, we describe the implications of the stakeholder meeting for our pilot study, which is slated to begin in the third quarter of 2020.

In its 2017 framework for PrEP implementation, the Kenya MOH identified research on the feasibility of integrating PrEP into pharmacies as “high priority” [26]. At this stakeholder meeting, the MOH confirmed its commitment to this objective by expressing support for this pharmacy-based PrEP delivery research and working with other key stakeholders to collaboratively develop a care pathway for pilot testing. A major strength of the resulting pathway is that it is grounded in expert knowledge of the Kenyan PrEP landscape. As such, the pathway leverages existing resources (e.g., NASCOP PrEP training materials) and incorporates innovative work-arounds to potential barriers (e.g., a novel checklist to help pharmacy providers establish PrEP client eligibility).

Expanding the scope of retail pharmacy practice to include interventions traditionally delivered at healthcare clinics is not new for Kenya. For years, retail pharmacies have delivered family planning methods (e.g., condoms, oral contraception, emergency contraception and, more recently, injectable contraception) that are available for free at public family planning clinics [14]. The pharmacy-based PrEP delivery model we aim to pilot test represents a shift toward de-medicalizing PrEP in the sense that some tasks previously reserved to clinicians (e.g., writing PrEP prescriptions) will be expanded to a new cadre: pharmacy providers. If pharmacy providers prove able to adequately assess PrEP eligibility, adherence, and side effects, and some PrEP clients opt to get PrEP at pharmacies rather than healthcare facilities, this could potentially help decongest health facilities while also satisfying PrEP clients who prefer pharmacy-based care and might face discrimination accessing PrEP at health facilities.

Similarly, this model — if successful — may prompt the Kenya MOH to reconsider HIV testing guidelines. According to guidelines by Kenya Medical Laboratory Technicians and Technologists Board, only trained laboratory technologist and technicians are legally allowed to conduct rapid provider-completed HIV testing in Kenya. Under these guidelines, the ongoing rapid HIV testing being conducted by nurses at health facilities and retail pharmacy providers is not permissible. For these reasons, we limited HIV testing in our pharmacy-based PrEP delivery pilot study to provider-assisted HIV self-testing, which was made permissible when HIV self-tests were introduced in Kenya in May 2017 [30]. There exists, however, a high demand for HIV testing at retail pharmacies, and among pharmacies that currently provide both rapid HIV tests and self-tests, rapid tests are roughly one-third the cost of self-tests. Revising guidelines on who is legally allowed to provide rapid HIV testing might be something for Kenyan stakeholders to consider in the future to expand access to HIV testing services and decrease the potential cost of pharmacy-based PrEP delivery.

Documentation of PrEP dispensing was another key concern raised during the stakeholder meeting because implementing partners at the MOH facilities set PrEP targets for health facilities that could potentially disincentivize facilities from referring PrEP clients to retail pharmacies. For the pilot study, it is important that PrEP dispensing records complement — and do not compete with — facilities’ PrEP dispensing targets. For this reason, the PrEP dispensed at pilot pharmacies was recommended to be under the MFL code of a nearby health facility so that it can count toward that facility’s target PrEP numbers. Accurate completion of NASCOP’s PrEP dispensing records (including the drugs that will be donated to the pilot pharmacies) is important for future PrEP procurement, including continued support from international organizations such as the United States President’s Emergency Plan for AIDS Relief, United States Agency for International Development, Global Fund, and others. A number of electronic drug dispensing tools have already been developed by the Pharmaceutical Society of Kenya and the Clinton Health Access Initiative for use in the Kenyan context, so we plan on modify existing tools to record pharmacy-based PrEP delivery in our pilot study.

This study has some limitations that are important to note. First, the pharmacy PrEP stakeholders who attended this Nairobi-based meeting were a highly selective group of individuals who had contributed, in some way, to the recent introduction and scale up of PrEP in Kenya. While an alternative group of stakeholders may have designed a different care pathway for pharmacy-based PrEP delivery, we believe the experiences of the stakeholders in this group helped informed the design of a care pathway with the greatest likelihood of success, particularly for the setting. Second, the pharmacy-based PrEP care pathway designed from this collaborative process does not include creatinine testing for PrEP initiation. In Kenya, creatinine testing is not formally required for starting PrEP if doing so would limit initiation [21]. Additionally, programmatic data suggest that < 3% of individuals initiating PrEP at public HIV clinics receive creatinine testing [32]. In individuals with no risk factors, renal compromise with PrEP use is an extremely rare outcome [33]; which is why, in our proposed care pathway, only healthy individuals with no pre-existing or emerging health conditions are eligible for PrEP initiation or continuation at retail pharmacies. Third, the care pathway for pharmacy-based PrEP delivery developed in this study has not yet been tested in Kenya. Before this model of PrEP delivery is scaled in Kenya, model weak points should identified and refined through pilot testing (forthcoming) and the effect of pharmacy-based versus facility-based PrEP delivery on PrEP uptake and continuation should be measured through a randomized trial. Finally, because Kenya was one of the first countries to deliver PrEP in sub-Saharan Africa, it has a more mature PrEP delivery program than other sub-Saharan African countries. For this reason, the pharmacy-based PrEP delivery care pathway developed by Kenyan stakeholders might have limited generalizability to settings outside Kenya and thus should be adapted to and tested in new settings before being implemented.

Conclusions

Through a collaborative stakeholder consultation process, we were able to successfully develop a care pathway for pilot testing of pharmacy-based PrEP delivery in Kenya. Despite the availability of highly effective HIV prevention interventions, high levels of population-level HIV incidence persist in many sub-Saharan African settings [1]. Novel strategies to expand the reach of HIV prevention services to those most at HIV risk remain needed, including moving HIV prevention services outside of clinical settings (e.g., pharmacies) to reach individuals that might never frequent health facilities for a multitude of reasons, including long wait times and HIV stigma [8,9,10]. In our consultation process, pharmacy PrEP stakeholders expressed strong enthusiasm and support for pharmacy-based PrEP delivery in Kenya [26, 28] and identified a number of challenges and potential solutions for implementing this novel model of PrEP delivery. Now generating evidence around the effectiveness of pharmacy-based PrEP on PrEP uptake and continuation is a necessary first step toward making this highly effective HIV prevention intervention accessible to those who need it.

Availability of data and materials

We have included the worksheets used by stakeholders as well as the PrEP prescribing checklist for pharmacy-based PrEP delivery as Appendices of this paper. Slides presented at the stakeholder meeting are available upon request.

Abbreviations

AIDS:

Acquired immunodeficiency virus

CHAI:

Clinton Health Access Initiative

HIV:

Human immunodeficiency virus

KMLTTB:

Kenya Medical Laboratory Technicians and Technologists Board

KEMSA:

Kenya Medical Supplies Agency

MFL:

Master facility list

MOH:

Ministry of Health

NASCOP:

National IADS & STI Control Program

PEPFAR:

President’s Emergency Plan for AIDS Relief

PPB:

Pharmacy and Poisons Board

PrEP:

Pre-exposure prophylaxis

PSK:

Pharmaceutical Society of Kenya

STIs:

Sexually transmitted infections

USAID:

United States Agency for International Development

References

  1. UNAIDS. Communities at the centre: defending rights, breaking barriers, reaching people with HIV services. Geneva: UNAIDS; 2019. Available from: https://www.unaids.org/sites/default/files/media_asset/2019-global-AIDS-update_en.pdf. Cited 2020 Apr 17.

    Google Scholar 

  2. Kenya Ministry of Health. Kenya AIDS response progress report 2018. Nairobi: National AIDS Control Council; 2018. Available from: https://www.lvcthealth.org/wp-content/uploads/2018/11/KARPR-Report_2018.pdf. Cited 2020 May 4.

    Google Scholar 

  3. Grant RM, Lama JR, Anderson PL, McMahan V, Liu AY, Vargas L, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010 Dec 30;363(27):2587–99.

    Article  CAS  Google Scholar 

  4. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012 Aug 2;367(5):399–410.

    Article  CAS  Google Scholar 

  5. Thigpen MC, Kebaabetswe PM, Paxton LA, Smith DK, Rose CE, Segolodi TM, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012 Aug 2;367(5):423–34.

    Article  CAS  Google Scholar 

  6. Choopanya K, Martin M, Suntharasamai P, Sangkum U, Mock PA, Leethochawalit M, et al. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir study): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2013 Jun 15;381(9883):2083–90.

    Article  Google Scholar 

  7. O’Malley G, Barnabee G, Mugwanya K. Scaling-up PrEP delivery in sub-Saharan Africa: what can we learn from the scale-up of ART? Curr HIV/AIDS Rep. 2019;16(2):141–50.

    Article  Google Scholar 

  8. Baeten JM, Heffron R, Kidoguchi L, Mugo NR, Katabira E, Bukusi EA, et al. Integrated delivery of antiretroviral treatment and pre-exposure prophylaxis to HIV-1-serodiscordant couples: a prospective implementation study in Kenya and Uganda. PLoS Med. 2016 Aug;13(8):e1002099.

    Article  Google Scholar 

  9. Mack N, Odhiambo J, Wong CM, Agot K. Barriers and facilitators to pre-exposure prophylaxis (PrEP) eligibility screening and ongoing HIV testing among target populations in Bondo and Rarieda, Kenya: Results of a consultation with community stakeholders. BMC Health Serv Res. 2014;14:231.

    Article  Google Scholar 

  10. Patel RC, Stanford-Moore G, Odoyo J, Pyra M, Wakhungu I, Anand K, et al. “Since both of us are using antiretrovirals, we have been supportive to each other”: facilitators and barriers of pre-exposure prophylaxis use in heterosexual HIV serodiscordant couples in Kisumu, Kenya. J Int AIDS Soc. 2016;19(1):21134.

    Article  Google Scholar 

  11. Bigogo G, Audi A, Aura B, Aol G, Breiman RF, Feikin DR. Health-seeking patterns among participants of population-based morbidity surveillance in rural western Kenya: implications for calculating disease rates. Int J Infect Dis. 2010 Nov;14(11):e967–73.

    Article  Google Scholar 

  12. Abuya TO, Mutemi W, Karisa B, Ochola SA, Fegan G, Marsh V. Use of over-the-counter malaria medicines in children and adults in three districts in Kenya: implications for private medicine retailer interventions. Malar J. 2007 May 10;6:57.

    Article  Google Scholar 

  13. Mayora C, Kitutu FE, Kandala N-B, Ekirapa-Kiracho E, Peterson SS, Wamani H. Private retail drug shops: what they are, how they operate, and implications for health care delivery in rural Uganda. BMC Health Serv Res. 2018;18(1):532.

    Article  Google Scholar 

  14. Corroon M, Kebede E, Spektor G, Speizer I. Key role of drug shops and pharmacies for family planning in urban Nigeria and Kenya. Glob Health Sci Pract. 2016;4(4):594–609.

    Article  Google Scholar 

  15. Ladner J, Davis B, Audureau E, Saba J. Treatment-seeking patterns for malaria in pharmacies in five sub-Saharan African countries. Malar J. 2017 Aug 29;16(1):353.

    Article  Google Scholar 

  16. Mugo PM, Prins HAB, Wahome EW, Mwashigadi GM, Thiong’o AN, Gichuru E, et al. Engaging young adult clients of community pharmacies for HIV screening in coastal Kenya: a cross-sectional study. Sex Transm Infect. 2015 Jun;91(4):257–9.

    Article  Google Scholar 

  17. Igun UA. Why we seek treatment here: retail pharmacy and clinical practice in Maiduguri, Nigeria. Soc Sci Med 1982. 1987;24(8):689–95.

    CAS  Google Scholar 

  18. Viberg N, Tomson G, Mujinja P, Lundborg CS. The role of the pharmacist-voices from nine African countries. Pharm World Sci PWS. 2007;29(1):25–33.

    Article  Google Scholar 

  19. Wafula FN, Miriti EM, Goodman CA. Examining characteristics, knowledge and regulatory practices of specialized drug shops in sub-Saharan Africa: a systematic review of the literature. BMC Health Serv Res. 2012 Jul 27;12:223.

    Article  Google Scholar 

  20. WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection - Second edition. Geneva: WHO; 2016.

    Google Scholar 

  21. Kenya Ministry of Health. Guidelines on the use of antiretroviral drugs for treating and preventing HIV infection in Kenya - 2018 edition. Nairobi: Kenya Ministry of Health; 2018. Available from: http://cquin.icap.columbia.edu/wp-content/uploads/2017/04/ICAP_CQUIN_Kenya-ARV-Guidelines-2018-Final_20thAug2018.pdf. Cited 2020 Apr 22.

    Google Scholar 

  22. Aywak D, Jaguga CDP, Nkonge NG, Kinuthia R, Ambale C, Awle IA. Pharmacy practice in Kenya. Can J Hosp Pharm. 2017;70(6):456–62.

    PubMed  PubMed Central  Google Scholar 

  23. Mugo PM, Micheni M, Shangala J, Hussein MH, Graham SM, de Wit TFR, et al. Uptake and acceptability of oral HIV self-testing among community pharmacy clients in Kenya: a feasibility study. PLoS One. 2017 Jan 26;12(1):e0170868.

    Article  Google Scholar 

  24. Tung EL, Thomas A, Eichner A, Shalit P. Implementation of a community pharmacy-based pre-exposure prophylaxis service: a novel model for pre-exposure prophylaxis care. Sex Health. 2018 Nov;15(6):556–61.

    Article  Google Scholar 

  25. Kelley-Ross Pharmacy Group. One-step PrEP. 2020. Available from: https://www.kelley-ross.com/polyclinic/prep/.

    Google Scholar 

  26. Kenya Ministry of Health. Framework for the implementation of pre-exposure prophylaxis of HIV in Kenya. Nairobi: National AIDS & STI Control Programme (NASCOP), Kenya Ministry of Health; 2017. Available from: https://www.prepwatch.org/wp-content/uploads/2017/05/Kenya_PrEP_Implementation_Framework-1.pdf.

    Google Scholar 

  27. PrEP Watch: Kenya. 2020. Available from: https://www.prepwatch.org/country/kenya/.

    Google Scholar 

  28. Mugambi M. NASCOP status updates: HTS/PrEP. Pharmacy PrEP Stakeholders Meeting. Nairobi; 2020.

  29. Pharmacy and Poisons Board. License Status: Pharmacy and Poisons Board. Available from: https://practice.pharmacyboardkenya.org/LicenseStatus. Cited 2020 May 20.

  30. Centre for Health Solutions - Kenya. National launch of PrEP and HIV self-testing guidelines. 2017. Available from: https://www.chskenya.org/media_centre/national-launch-prep-hiv-self-testing-guidelines/. Cited 2020 Apr 21.

    Google Scholar 

  31. Kenya Ministry of Health. The Kenya HIV testing services guidelines. Nairobi: Kenyan Ministry of Health; 2015. Available from: https://aidsfree.usaid.gov/sites/default/files/hts_policy_kenya_2015.pdf. Cited 2017 Aug 20.

    Google Scholar 

  32. Irungu E, Ngure K, Mugwanya K, Mugo N, Bukusi E, Odoyo J, Wamoni W, Morton J, O'Malley, G, Baeten. Surmounting PrEP delivery challenges through adaptation of implementation guidelines: Lessons learned from HIV care clinics in Kenya. IAS 2019: 10th IAS Conference on HIV Science, Mexico City, Mexico, July 21–24, 2019. Abstract WEPDC0204.

  33. Mugwanya K, Baeten JM, Wyatt C, Mugo NR, Celum C, Ronald A, et al. Frequency of monitoring kidney function in HIV-uninfected persons using daily oral tenofovir disoproxil fumarate pre-exposure prophlyaxis. J Acquir Immune Defic Syndr. 2018;77(2):206–11.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to acknowledge all the Stakeholders for Pharmacy-based PrEP Delivery who participated in our January 2020 meeting: Binti Tsala (Kenya Medical Laboratory Technicians & Technologists Board); Nancy Cherutich (Pharmacy and Poisons Board); Mary Mugambi, Abdullahi Sheikh, Mariah Mensah and Helgar Musyoki (National AIDS & STI Control Program); Benjamin Mbugua (Kenya Pharmaceutical Association & Huruma Pharmacy); Louis Somoni (Pharmaceutical Society of Kenya); Elizabeth Gitau (Kenya Medical Association); Faith Tonui (WACI Health); Mercy Mutonyi (2019 AVAC Fellow); Jeffery Walimbwa (ISHTAR); George Mugendi (University of Nairobi); Daniel Were (JHPIEGO, Jilinde program); Victoria Wanjohi (Clinton Health Access Initiation); Judy Kariuki (Thika Level 5 Hospital); Nancy Abuya (Mbagathi Hospital); Victoria Liaka (Ruiru Hospital); Beatrice Wachira (Karatina Hospital) and Moraa Kiangoi (Leleshwa Pharmacy); We would also like to thank other collaborators on this project who were not able to attend this meeting: Peter Mugo (Kenya Medical Research Institute), Elyse Tung (Kelley-Ross Pharmacy), Renee Heffron (University of Washington), Pamela Kohler (University of Washington), and Andy Stergachis (University of Washington).

Funding

This study was funded by the National Institute of Mental Health (R34 MH120106). KFO received additional support from the National Institute of Mental Health (K99 MH121166) and the National Institute of Allergy and Infectious Disease (P30 AI027757). The funders had no role in the design or implementation of this study.

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Contributions

K.F.O., S.R., J.B., K.N., P.M., E.B., K.K., E.T., A.S., P.K., P.M., R.H. and J.O. organized the stakeholder meeting, invitations, and presentations. K.F.O., S.R., J.B., K.N., P.M., E.I., E.B., K.K., J.O., J.P., N.R.M., and E. S helped facilitate the stakeholder meeting and small group discussions. All authors (with the exception of E.T., A.S., P.K., P.M., R.H.) participated in the one-day stakeholder meeting and contributed to the developing the care pathway for pharmacy-based PrEP delivery in Kenya. K.F.O. drafted the paper. All authors reviewed and edited the final manuscript.

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Correspondence to Katrina F. Ortblad.

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Ethics approval and consent to participate

We received ethical approval to conduct formative research, including engagement with stakeholders during a one-day meeting, from institutional review boards at the Kenya Medical Research Institute (KEMRI) and University of Washington (UW). Because stakeholders were involved in the collaborative development of the care pathway and were not research subjects themselves, the need for individual stakeholder consent was waived by the KEMRI and UW institutional review boards. All stakeholders reviewed and approved this manuscript for publication and have been acknowledged for their participation in the care pathway development process.

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Not applicable.

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The authors of this paper declare no competing interests.

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Supplementary Information

Additional file 1:

Appendix I. Stakeholder organizations in attendance at the January 2020 meeting.

Additional file 2:

Appendix II. Pharmacy-based PrEP delivery – Worksheet #1.

Additional file 3:

Appendix III. Pharmacy-based PrEP delivery – Worksheet #2.

Additional file 4:

Appendix IV. Pharmacy PrEP prescribing Checklist.

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Ortblad, K.F., Mogere, P., Roche, S. et al. Design of a care pathway for pharmacy-based PrEP delivery in Kenya: results from a collaborative stakeholder consultation. BMC Health Serv Res 20, 1034 (2020). https://0-doi-org.brum.beds.ac.uk/10.1186/s12913-020-05898-9

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