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Table 1 Characteristics of guidelines included in this study

From: A technical appraisal of guidelines for the management of skin rash in patients on chemotherapy and targeted therapy

Title

Year of publication

Country/region

Level of development

Organization

Authors number

Number of references

Type of guideline

EGFR inhibitor-associated cutaneous toxicities: An Evolving Paradigm in Clinical Management [21]

2007

USA

International

Not specified

6

58

CBG

Clinical significance and treatment of skin rash from erlotinib in NSCLC patients: results of an Experts Panel Meeting [22]

2008

Italy

National

Not specified

15

37

CBG

An interdisciplinay consensus on managing skin reactions associated with EGFRI [23]

2008

USA

National

Not specified

3

31

CBG

Expert consensus on the management of erlotinib-associated cutaneous toxicity in the UK [24]

2009

UK

National

Not specified

9

28

CBG

Sunitinib in metastatic renal cell carcinoma: recommendations for management of noncardiovascular toxicities [25]

2011

Canada, USA France,

International

Not specified

16

55

CBG

Management of cutaneous side effects of EGFR inhibitors: recommendation from a German expert panel [26]

2011

Germany

National

Not specified

12

36

CBG

Clinical practice guideline for the prevention and treatment of EGFR inhibitor-associated dermatologic toxicities [27]

2011

France, Italy, USA,Singapore

International

Skin toxicity study group (STSG)

7

114

EBG

Interdisciplinary management of EGFR-inhibitor- induced skin reactions: a German expert opinion [28]

2011

Germany

National

Not specified

12

81

CBG

Management of skin toxicity associated with cetuximab treatment in combination with chemotherapy or radiotherapy [29]

2011

Italy

National

Not specified

7

68

CBG

Management of cutaneous adverse events induced by anti-EGFR: a French interdisciplinary therapeutic algorithm [30]

2012

France

National

Not specified

21

32

CBG

Clinical practice guideline for the prevention and treatment of rash in patients treated with EGFR inhibitor therapies [31]

2012

Canada

Regional

TGHNTT

Not specified

73

CBG

Daily baseline skin care in the prevention, treatment, and supportive care of skin toxicity in oncology patients: recommendation from a multinational expert panel [32]

2013

Europe

International

No specified

7

48

CBG

Management of the adverse events of afatinib: a consensus of the recommendations from the Spanish expert panel [33]

2015

Spain

National

No specified

8

34

CBG

Expert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK [34]

2015

UK

National

No specified

13

46

CBG

Practical recommendations for rash and diarrhea management in Indian patients treated with TKI for the treatment of NSCLC [35]

2016

India

National

No specified

11

7

CBG

Management of skin reactions during cetuximab treatment in association with chemotherapy or radiotherapy: update of the Italian expert recommendations [36]

2016

Italy

National

No specified

7

53

CBG

BRAF/MEK Inhibitor Therapy: Consensus Statement on Managing Adverse Events and Potential Drug Interactions [37]

2017

USA

National

The Melanoma Nursing Initiative

2

33

CBG

Prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities [38]

2017

China

Regional

TDA

6

33

CBG

Putting evidence into practice: skin reactions [39]

2017

USA

National

ONS

10

98

EBG

  1. Abbreviations: EGFR epidermal growth factor receptor, ESMO European society for medical oncology, NSCLC non-small cell lung cancer, TDA Taiwanese Dermatological Association, TGHNTT thoracic malignancies, gastrointestinal, head and neck tumour teams, TKIs tyrosine kinase inhibitors, ONS oncology nursing society