Table 12 List of potential PRIMEtime CE sensitivity analyses

Changing the time horizon.

Time horizon changing from 10 years in the primary analysis to 1 year, 5 years, 20 years, and 100 years (lifetime of the cohort).

Analysing results from an NHS perspective.

Estimating cost effectiveness using the change in NHS costs and intervention costs only (without any societal costs).

Analysing results from a social care perspective.

Estimating cost effectiveness using the change in social care and intervention costs only (without any NHS costs).

Including social care costs and productivity.

Adding an economic estimate of changes to productivity arising from the intervention.

Including all wider societal costs.

Including an economic estimate of the intervention on all wider societal costs (including productivity and social care costs).

Using a discount rate of 3.5%.

Changing the discount rate for costs and outcomes from 1.5 to 3.5%.

No disease costs estimated for diseases not explicitly modelled by PRIMEtime CE (unrelated disease costs).

Removing from the model any NHS and social care costs estimated to accrue due to diseases that are not explicitly modelled by PRIMEtime CE.

No cancer included in the model

Cancer removed from the model so that only IHD, stroke, type two diabetes, and liver cirrhosis are included.

Only including diseases directly related to the risk factor affected.

For a diet intervention, only IHD and stroke are included in the model, and for a physical activity intervention, IHD, stroke, type two diabetes, breast cancer, and colorectal cancer are included.