Table 3 Rates and rate ratios with 95%CIs for antibacterial therapy by drug class
Drug class | Observed rate (whole ICU cohort) a | Observed rate patients aged < 80 yearsa | Observed rate patients aged ≥ 80 yearsa | Unadjusted rate ratio ≥ 80 vs. < 80b | Adjusted rate ratio ≥ 80 vs. < 80c |
|---|---|---|---|---|---|
All Antibacterials | 38.70 (38.26–39.15) | 39.73 (39.25–40.21) | 30.97 (29.84–32.15) | 0.99 (0.94–1.03) | 1.02 (0.98–1.07) |
All antibacterials except erythromycin | 32.81 (32.41–33.22) | 33.49 (33.05–33.93) | 27.69 (26.63–28.81) | 1.05 (1.00–1.10) | 1.07 (1.02–1.12) |
Tetracyclines | 0.87 (0.81–0.94) | 0.94 (0.86–1.01) | 0.41 (0.30–0.57) | 2.26 (1.59–3.22) | 1.87 (1.25–2.81) |
Penicillins | 8.43 (8.23–8.64) | 8.36 (8.14–8.58) | 9.01 (8.41–9.66) | 1.41 (1.29–1.53) | 1.37 (1.26–1.48) |
Cephalosporins | 9.02 (8.81–9.24) | 9.20 (8.97–9.43) | 7.70 (7.15–8.30) | 1.22 (1.11–1.34) | 1.20 (1.09–1.31) |
Carbapenems | 8.08 (7.88–8.28) | 8.58 (8.36–8.80) | 4.32 (3.91–4.77) | 1.29 (1.15–1.44) | 1.35 (1.20–1.50) |
Macrolides | 14.52 (14.26–14.80) | 15.36 (15.07–15.66) | 8.21 (7.63–9.82) | 0.96 (0.88–1.04) | 0.97 (0.90–1.06) |
Clarithromycin | 0.18 (0.16–0.22) | 0.18 (0.15–0.22) | 0.19 (0.12–0.31) | 1.17 (0.64–2.14) | 1.02 (0.51–2.04) |
Lincosamides | 0.73 (0.67–0.80) | 0.69 (0.63–0.75) | 1.06 (0.87–1.30) | 1.41 (1.08–1.83) | 1.40 (1.05–1.86) |
Aminoglycosides | 0.49 (0.45–0.55) | 0.53 (0.48–0.59) | 0.18 (0.11–0.29) | 1.12 (0.61–2.04) | 1.11 (0.61–2.02) |
Fluoroquinolones | 7.20 (7.02–7.40) | 7.34 (7.13–7.54) | 6.22 (5.72–6.76) | 1.24 (1.12–1.37) | 1.17 (1.05–1.30) |
Glycopeptides | 0.41 (0.37–0.46) | 0.44 (0.39–0.49) | 0.19 (0.12–0.31) | 2.16 (1.14–4.10) | 1.69 (0.90–3.20) |
Imidazoles | 7.94 (7.74–8.14) | 7.85 (7.64–8.06) | 8.59 (8.00–9.22) | 1.36 (1.25–1.48) | 1.34 (1.23–1.46) |
Oxazolidinones | 4.33 (4.19–4.48) | 4.69 (4.53–4.85) | 1.64 (1.40–1.93) | 1.22 (1.02–1.47) | 1.30 (1.08–1.56) |