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Table 1 Comparison of the features of different ovarian stimulation protocol

From: Assessment of the development of assisted reproductive technology in Liaoning province of China, from 2012 to 2016

Protocol Year

Super long GnRH agonist

Standard long GnRH agonist

Short GnRH agonist

GnRH antagonist

Mild stimulation

Natural cycle

Percentage of different ovarian stimulation protocol (%)

 2012

4.38

58.31

22.57

8.30

4.93

1.51

 2013

4.03

68.77

11.25

6.19

6.81

2.94

 2014

4.71

62.65

13.51

4.95

10.23

3.95

 2015

4.67

53.59

8.40

15.16

13.61

4.58

 2016

6.24

43.69

4.60*

26.39

12.89*

4.65*

Number of retrieved oocytes

 2012

7.63

11.94

8.27

6.29

3.50

0.93

 2013

9.99

11.42

7.69

6.42

2.80

0.82

 2014

8.41

11.30

7.45

5.69

2.43

0.69

 2015

10.87

11.04

7.23

6.31

2.32

0.72

 2016

13.00

12.00

6.03*

6.70

2.24*

0.73

Implantation rates (%)

 2012

27.53

31.58

22.22

17.65

12.26

18.60

 2013

29.07

31.18

20.67

21.74

16.19

18.89

 2014

33.64

33.17

23.71

20.86

15.06

22.73

 2015

33.94

34.65

25.14

24.47

17.42

18.33

 2016

31.21

34.60*

25.58

25.11*

17.01

21.97

Clinical pregnancy rates (%)

 2012

45.59

48.56

33.42

29.27

18.34

26.03

 2013

49.26

49.68

33.25

36.70

24.72

18.99

 2014

53.63

49.77

37.58

35.22

22.85

21.30

 2015

49.75

53.14

41.75

39.01

31.33

20.75

 2016

49.44

52.90*

42.32*

39.41

25.69

22.73

Early abortion rates (%)

 2012

12.44

11.79

14.79

19.74

24.66

26.32

 2013

8.58

7.42

6.44

10.00

10.91

0.00

 2014

9.41

10.68

9.98

15.52

15.38

8.70

 2015

9.09

7.63

6.64

11.15

11.96

0.00

 2016

8.63

8.53

11.31

9.05

14.88

16.00

Ectopic pregnancy rates (%)

 2012

1.84

2.94

2.47

3.86

4.11

0.00

 2013

4.29

2.40

4.46

10.50

3.64

13.33

 2014

1.76

1.62

3.21

4.60

3.08

0.00

 2015

1.35

2.29

3.65

2.69

0.48

4.55

 2016

1.52

2.72

0.60

3.34

1.65

0.00

Multiple pregnancy rates (%)

 2012

22.58

27.95

27.26

24.46

13.70

0.00

 2013

32.62

26.09

24.01

24.00

18.18

13.33

 2014

26.76

31.19

32.26

21.26

16.15

8.70

 2015

35.35

31.48

31.23

22.12

6.70

4.55

 2016

20.05

27.55

23.21

21.66

14.05

16.00

Average dose of gonadotropin (IU)

 2012

3101.25

2356.5

2251.5

2379.75

1019.25

0

 2013

3190.5

2541

2342.25

2201.25

945.75

9

 2014

3342.75

2598

2406

2372.25

852.75

0

 2015

3192

2560.5

2379

2419.5

913.5

9

 2016

2678.25

2461.5

2418.75

2347.5

1176

37.5

  1. *p < 0.05, represents a significant time trend in the each data from 2012 to 2016