Table 4 Sensitivity analyses of CMA (95% confidence intervals) by number of filled statin prescriptions and switching between statins
Number of filled prescriptions | Switching between different statins | ||||||||
|---|---|---|---|---|---|---|---|---|---|
≥ 2 filled statin prescriptions | No switches | 1-3 switches | |||||||
N | Mean (%) | 95% CI | N | Mean (%) | 95% CI | N | Mean (%) | 95% CI | |
Entire study population | |||||||||
Simvastatin users with generic substitution | 94525 | 90.1 | 89.9-90.3 | 93572 | 86.9 | 86.0-87.8 | 7423 | 83.1 | 82.0-84.1 |
Simvastatin users with active decline of generic substitution | 697 | 79.8 | 84.7-86.8 | 533 | 68.1 | 56.4-79.9 | 268 | 80.2 | 74.6-85.7 |
Simvastatin users not exposed to generic substitution | 2911 | 52.5 | 76.6-83.0 | 5651 | 49.3 | 45.7-52.9 | 1292 | 75.9 | 73.4-78.5 |
Atorvastatin users | 6616 | 85.8 | 50.9-54.0 | 6172 | 79.6 | 76.2-83.1 | 1359 | 67.0 | 64.6-69.5 |
Those with generic substitution | |||||||||
Generic substitution at first purchase | 57844 | 88.7 | 88.4-89.1 | 59175 | 83.7 | 83.0-84.4 | 5139 | 80.7 | 79.6-81.8 |
Generic substitution later on | 36681 | 92.2 | 91.8-92.5 | 34297 | 92.4 | 91.4-93.4 | 2284 | 88.4 | 86.8-90.1 |