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Table 1 Overview of human cell-derived wound care products for the management of chronic leg ulcers investigated by health economic evaluation

From: Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers

Product

Description

Indications

Manufacturer

Apligraf®

Bi-layered skin substitute: the epidermal layer is composed of human keratinocytes; the dermal layer is formed by human fibroblasts in a bovine type I collagen matrix

â–ª Non-infected partial and full-thickness venous leg ulcers

â–ª Full-thickness neuropathic diabetic foot ulcers

Organogenesis, US

Becaplermin (REGRANEX® Gel)

Clear colourless to straw-coloured gel, which contains 0.01% of the active substance becaplermin

â–ª Deep neuropathic diabetic foot ulcers

Systagenix Wound Management, US

Dermagraft®

Cryopreserved human fibroblast-derived dermal substitute composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold

â–ª Full-thickness diabetic foot ulcers

Advanced BioHealing, US