Table 2 Cost, outcome, cost-effectiveness ratio and incremental cost-effectiveness ratio (ICER) of providing unstimulated IUI (U-IUI), gonadotrophin stimulated IUI (S-IUI) and clomifene stimulated IUI (C-IUI) to a hypothetical cohort of couples with unexplained or male factor subfertility.
U-IUI (LBR = 3.5%) | Full cycle of IVF | Overall | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Order of cycle | No. of cycles | Live- birth Deli-very from IUI | Cost £ | Cost/outcome (£/delivery) | No. of couples having one full cycle of IVF | Live birth delivery from one full cycle of IVF | Cost £ | Total live birth delivery (IUI+ IVF) | Total cost £ | Total cost/total outcome (£/Delivery) | ICER |
U-IUI (LBR-3.5%) | |||||||||||
0 | 0 | 0 | 0 | 100 | 26 | 321,700 | 26 | 321,700 | 12,600 | Ref | |
1 | 100 | 4 | 44,900 | 12,800 | 87 | 22 | 279,400 | 26 | 324,300 | 12,700 | 18,600 |
2 | 196 | 7 | 88,200 | 12,800 | 84 | 21 | 269,600 | 28 | 357,900 | 12,600 | 13,200 |
3 | 293 | 10 | 131,600 | 13,000 | 81 | 21 | 260,200 | 31 | 391,800 | 12,700 | 13,400 |
4 | 390 | 13 | 175,000 | 13,200 | 78 | 20 | 251,100 | 33 | 426,100 | 12,800 | 13,600 |
5 | 487 | 16 | 218,500 | 13,400 | 75 | 20 | 242,300 | 36 | 460,800 | 13,000 | 13,900 |
6 | 584 | 19 | 262,000 | 13,600 | 73 | 19 | 233,800 | 38 | 495,900 | 13,100 | 14,200 |
S-IUI (LBR = 7%) | |||||||||||
0 | 0 | 0 | 0 | 100 | 26 | 321,700 | 26 | 321,700 | 12,600 | Ref | |
1 | 100 | 7 | 100,500 | 14,400 | 84 | 21 | 269,300 | 28 | 369,800 | 13,000 | 24,000 |
2 | 193 | 14 | 194,000 | 14,400 | 78 | 20 | 250,400 | 33 | 444,400 | 13,300 | 17,500 |
3 | 286 | 20 | 287,900 | 14,700 | 72 | 19 | 232,900 | 38 | 520,800 | 13,700 | 16,600 |
4 | 380 | 25 | 382,300 | 15,200 | 67 | 17 | 598,900 | 42 | 598,900 | 14,100 | 17,300 |
5 | 475 | 30 | 477,200 | 15,700 | 63 | 16 | 678,600 | 46 | 678,600 | 14,600 | 17,800 |
6 | 570 | 35 | 572,400 | 16,200 | 58 | 15 | 759,800 | 50 | 759,800 | 15,100 | 18,300 |
C-IUI (LBR = 3%) | |||||||||||
0 | 0 | 0 | 0 | 100 | 26 | 321,700 | 26 | 321,700 | 12,600 | Ref | |
1 | 100 | 3 | 75,200 | 25,100 | 87 | 22 | 280,900 | 25 | 356,000 | 14,000 | * |
2 | 197 | 6 | 148,100 | 24,700 | 85 | 21 | 272,400 | 28 | 420,600 | 15,300 | 49,400 |
3 | 294 | 9 | 221,200 | 24,600 | 82 | 21 | 264,000 | 30 | 485,200 | 16,300 | 40,900 |
4 | 391 | 12 | 294,200 | 24,500 | 79 | 20 | 255,600 | 32 | 549,700 | 17,200 | 38,000 |
5 | 488 | 15 | 367,200 | 24,500 | 77 | 20 | 247,100 | 34 | 614,300 | 17,900 | 36,600 |
6 | 585 | 18 | 440,200 | 24,500 | 74 | 19 | 238,700 | 37 | 678,900 | 18,600 | 32,500 |