Assumption | Source |
---|---|
There is an 1:1 ratio between "fresh" and "frozen" cycles, assuming 25% of couples have 0 FET, 50% have 1 FET and 25% have 2 FET | Hypothetical assumption, based on informed judgement |
IVF and IVF/ICSI ratio is 1:1 | Hypothetical assumption, based on informed judgement |
100% compliance and 0% drop out with IUI treatment | Hypothetical assumption, based on informed judgement |
Effectiveness | |
LBR following a "full" IVF (IVF/ICSI) cycle is 19.26% (all ages) | HFEA 1995–19991 |
LBR following "frozen" IVF (IVF/ICSI) cycle is 10.40% (all ages) | HFEA 1995–19991 |
LBR following unstimulated IUI is 3.5% per cycle | Informed judgement, based on local data on effectiveness of stimulated IUI and by halving this, peer-reviewed literature11 |
LBR following gonadotrophin-stimulated IUI is 7% per cycle | Based on local activity data |
LBR following clomifene- stimulated IUI is 3% | Informed judgement, local activity data, and peer reviewed literature 12 |
Cost | |
-Cost of "fresh" IVF (IVF/ICSI) is £3,214 assuming 50% of "fresh" cycles will be ICSI cycles -Cost of "frozen" IVF (IVF/ICSI) is £450 -Cost of unstimulated IUI is £449 -Cost of stimulated IUI is £1005 -Cost of Clomiphene stimulated IUI is £752 | NICE estimates1 |
90% of couples who fail IUI proceed to IVF | Hypothetical, based on informed judgement |