- Research article
- Open Access
- Open Peer Review
“Home is where the patient is”: a qualitative analysis of a patient-centred model of care for multi-drug resistant tuberculosis
© Horter et al.; licensee BioMed Central Ltd. 2014
- Received: 19 December 2012
- Accepted: 13 February 2014
- Published: 21 February 2014
Ambulatory, community-based care for multi-drug resistant tuberculosis (MDR-TB) has been found to be effective in multiple settings with high cure rates. However, little is known about patient preferences around models of MDR-TB care. Médecins Sans Frontières (MSF) has delivered home-based MDR-TB treatment in the rural Kitgum and Lamwo districts of northern Uganda since 2009 in collaboration with the Ministry of Health and the National TB and Leprosy Programme. We conducted a qualitative study examining the experience of patients and key stakeholders of home-based MDR-TB treatment.
We used semi-structured interviews and focus-group discussions to examine patients’ perceptions, views and experiences of home-based treatment and care for MDR-TB versus their perceptions of care in hospital. We identified how these perceptions interacted with those of their families and other stakeholders involved with TB. Participants were selected purposively following a stakeholder analysis. Sample size was determined by data saturation being reached within each identified homogenous category of respondents: health-care receiving, health-care providing and key informant. Iterative data collection and analysis enabled adaptation of topic guides and testing of emerging themes. The grounded theory method of analysis was applied, with data, codes and categories being continually compared and refined.
Several key themes emerged: the perceived preference and acceptability of home-based treatment and care as a model of MDR-TB treatment by patients, family, community members and health-care workers; the fear of transmission of other infections within hospital settings; and the identification of MDR-TB developing through poor adherence to and inadequate treatment regimens for DS-TB.
Home-based treatment and care was acceptable to patients, families, communities and health-care workers and was seen as preferable to hospital-based care by most respondents. Home-based care was perceived as safe, conducive to recovery, facilitating psychosocial support and allowing more free time and earning potential for patients and caretakers. These findings could contribute to development of an adaptation of treatment approach strategy at national level.
- Multi-drug resistant tuberculosis (MDR-TB)
- Home-based care
Multi-drug resistant tuberculosis (MDR-TB) is defined as disease caused by Mycobacterium tuberculosis that is resistant to at least rifampicin and isoniazid. It can be acquired primarily through direct infection or can develop secondarily through inadequate treatment of drug-susceptible TB (DS-TB). Its treatment is lengthy, complex and can cause severe side effects. MDR-TB is an emerging issue globally; in 2011, 630 000 of the 12 million prevalent TB cases were MDR .
Historically, the model of MDR-TB treatment has been hospital-based, with patients admitted to a central institution for the intensive phase of treatment or longer, which usually means a minimum of 8 months . Hospital-based models of treatment are costly and often unfeasible both for patients and health systems [3, 4]. Only 16% of the cases of MDR-TB estimated to exist among notified TB patients were enrolled on treatment in 2010 .
Ambulatory, community-based care, whereby treatment is administered on an outpatient basis from a local community-based clinic often directly to patients in their homes (home-based care), has been found to be effective in multiple settings with high cure rates [4, 6, 7]. Treatment at the community level is feasible and safe and enables wider health influencing factors to be addressed including psychosocial support [8, 9]. In addition, community-based models of care are three to four times cheaper than hospital-based approaches [3, 10]. WHO now recommends MDR-TB treatment models that are primarily ambulatory [11, 12]. However, little is known about patient and staff acceptability of community-based care in sub-Saharan Africa [13, 14].
Uganda is classed as having a high burden of TB with approximately 63 000 TB cases in 2011 (183/100 000 population) . An estimated 1.4% of new and 12% of previously treated TB cases are MDR, which means there were around 1000 new cases of MDR TB in 2011 . Nearly 90% of Uganda’s population live in rural areas  and geographic access to health facilities is sub-optimal. 72% of people were reported as living within 5km of the nearest health facility in 2005, with the northern and eastern regions of Uganda having the poorest access to health-care services . Kitgum and Lamwo are two adjacent rural districts in northern Uganda which are currently comparatively stable but historically have been subjected to conflict and displacement, with devastating effects on the socio-economic status of the population and health infrastructure.
Until recently there was no national MDR-TB treatment programme in Uganda, with Médecins Sans Frontières (MSF) being the sole treatment provider, delivering home-based MDR-TB treatment in Kitgum and Lamwo districts since 2009 in collaboration with the Ministry of Health (MoH) and the National TB and Leprosy Programme. The national DS-TB treatment provision has had associated drug shortages due to reasons including staff capacity at local and district level to prepare quality and timely anti-TB drug orders and at central level due to late preparation of drug orders and poor logistical support.
MDR-TB patients, under MSF’s home-based treatment and care programme, receive individualised treatment regimens according to drug-susceptibility testing (DST) results and WHO guidelines, following the DOT approach as part of the Stop TB Strategy, as well as receiving education, psychosocial support and enablers such as food rations. HIV co-infected patients in need of treatment are offered integrated HIV care within MDR-TB related activities. Initial treatment is delivered in a local isolation unit (at Madi Opei Health Centre, Lamwo district; or Kitgum Government Hospital) until the patient is clinically stable and can be accommodated in a separate sleeping hut (‘tukul’) at home. The remainder of the 18-24 months of treatment is then delivered at home six days per week, directly observed by health-care workers, who are employed by MSF.
The MSF MDR-TB programme has achieved good results . However, the acceptability and accessibility of this model of care was not known. Although the Stop TB Strategy highlights the importance of patient-centred models of care  research on patients’ opinions and preferences is scarce. We conducted a qualitative study examining the experience of patients and key stakeholders with the aim of determining the acceptability and accessibility of the MDR-TB home-based treatment and care programmes in Kitgum and Lamwo. We also aimed to learn lessons from the programme implementation and obtain information to guide the development and future implementation of this model of care.
We conducted a qualitative research study using semi-structured interviews and focus-group discussions in August and September 2011. We examined patients’ opinions, views and experiences of home-based treatment and care for MDR-TB versus their assertions of care in hospital. We also identified how these views compared with those of their families and other stakeholders involved with TB. These methods were chosen due to the exploratory nature of the research question, with interviews allowing an in-depth view to the opinions and experiences of respondents, and focus-group discussions showing group dynamics and general consensus versus anomalies regarding this topic. The principal investigator did not occupy the dual role of clinician and researcher, and therefore maintained a level of independence to reduce study bias.
Participants were identified and selected purposively following a stakeholder analysis, whereby all actors with a relationship to the topic (home-based treatment and care or MDR-TB) were mapped, and their likely view towards home-based treatment was rated from 1 to 5, with 1 being strongly negative view and 5 being strongly positive view. This mapping exercise also considered their likely influence, interest in the issue and any assumptions made. A range of different actors were then invited for interview through routine programme activities in order to explore the diversity of opinions on this topic. The principal investigator approached all identified participants outlining the study and requesting voluntary interview/focus-group discussion participation. Interviews and focus group discussions were audio-recorded and lasted around 60 and 90 minutes, respectively. Sample size was determined by data saturation being reached within each identified homogenous category of respondents: health-care receiving, health-care providing and key informants .
Interviews were based on the use of interview guides with prompts, allowing a participant-led and flexible approach to data collection. Interviews were structured around a core set of topics, including introductions, patient or family members’ experience of MDR-TB, as well as diagnosis and treatment; and their views on recommendations for future treatment provision. Conversation around these topics was participant-led and naturally flowed. Prompts and probes allowed particular topics to be explored in more depth, for example on asking patients if they spoke about having MDR-TB openly, it was then possible to explore their response to ascertain whether there was a fear of negative response or stigma. This approach allows for exploration of particular topics whilst still being participant-led and not risking asking leading questions. Topics used in health care provider and key informant interviews were slightly different, including an examination of the current system of treatment and care, acceptability of home-based care, adherence and stigma. An interpreter was used to translate questions and responses from Luo to English and vice versa in several interviews and discussions. A separate independent interpreter was used to re-translate interview recordings where possible to ensure validity of interpretations. Data were analysed throughout the entire course of the research, in that from the moment data were being generated the “thinking and theorising” began . This iterative process of data collection and analysis enabled adaptation of topic guides and testing of emerging themes. For example, following analysis of initial patient interviews a code around patient adherence to MDR-TB treatment emerged, which led to this being added as a specific topic within interview guides in order for this to be explored further. Data were managed initially through verbatim transcription of all recorded conversational interviews. Systematic analysis of transcripts was conducted to identify codes, relevant themes, patterns and concepts compatible to a deductive grounded theory approach. A framework analysis was used to subdivide the data as well as assign categories to ascertain the most significant themes and patterns, with relationships between constructs, as well as deviant cases, being identified [20, 21].
Formal ethics approval was gained from the London School of Hygiene and Tropical Medicine, MSF Ethics Review Board and Ugandan Ethics Review Board prior to the study commencing. Prior to interview commencement and recording all participants voluntarily gave their informed written consent. Confidentiality of respondents was ensured through the use of pseudonyms and data storage protection procedures. Feedback mechanisms were used to ensure participants were aware of the findings of the study and could choose to opt out.
There were nine MDR and two mono-resistant patients receiving treatment at the time of the study; previously one MDR and three mono-resistant patients had completed treatment and been cured. All patients live in small villages in remote rural settings and 63% of the population in this region live below the poverty line .
Data saturation was reached in each respondent category after 30 interviews: 12 health-care receiving, nine health-care providing and nine key informant. Saturation was defined as occurring when themes that emerged in each respondent group were reiterated by different participants; and when additional participant transcript analysis revealed no new themes. Respondents included MDR-TB patients currently in the MSF home-based treatment and care programme (n = 7), their family members (5), health-care workers (6), village health team members (3) and identified key informants from the MoH (2) and non-governmental organisations (7). The two MDR-TB patients who did not participate in the study did so due to logistical reasons regarding time availability and working hours. All other approached participants voluntarily agreed to being interviewed.
Patients who agreed to participate were both male (4) and female (3), their ages ranged from 15 to 70 years and they were all from low socio-economic backgrounds, the majority being illiterate. Responses were analysed to account for gender and age differences; but these demographic factors did not influence the themes that emerged. A total of four focus group discussions were conducted: one with village health team members (6) and three with community members (10, 11 and nine participants). Village health team members are governmentally employed but in principle are volunteers, paid mainly in incentives and a small stipend to perform a role similar to community health workers. This focus group included three males and three females. The community member focus groups were held with members of a similar age and the same gender to minimise the effects of power dynamics. Two focus groups were held with groups of females (one with young females and one with older) and one was held with young men.
Perceived preference for home-based treatment and care and high acceptability
‘I feel that getting treatment at home is better than hospital.’ Patient 01
All twelve patients and family members interviewed stated a preference for home-based care over hospital-based care, with some mentioning that this was conditional to the drug supply being constant and reliable. Acceptability of this model of care was high: home-based treatment and care was accepted by all health-care receiving respondents; the two district MoH respondents; all three village health team respondents; and five of the six health-care worker respondents. The one health-care worker respondent who was ambivalent was a nurse who feared secondary transmission within the community. The majority of community members who participated in focus group discussions stated a preference for home-based treatment and none mentioned a lack of acceptance of having patients in their communities being treated for MDR-TB at home. All members of village health teams interviewed said they would be willing to deliver MDR-TB treatment at home.
Home was perceived as an environment which:
Is more conducive to recovery than hospital:
‘I saw during the home-based care period patients get a lot of improvement in home than in the hospital.’ Family member 05
‘I think from home someone recovers much faster than when hospitalised.’ Health-care worker 03
Enables more psychosocial support due to the closeness of family and friends and perceived connectedness in comparison with feelings of isolation and loneliness associated with hospital admission:
‘Having people coming home, chatting with you, it is nice and encourages you to take the drugs.’ Patient 02
Provides free time for both the caretaker and the patient to conduct other activities such as performing small jobs and having social interactions.
‘If I was in the hospital in Kampala the cost for transport is very expensive and someone must come to see you and stay for 1 month maybe, then they cannot do other things in this time and it would be very costly.’ Patient 02
‘Because the patient comes from a poor family, he cannot raise the money to go to Mulago [National Referral Hospital in Kampala]’ MoH 02
Fears of transmission of MDR-TB and other infections
No patient or family respondents mentioned fears or association of treatment at home with heightened risk of secondary transmission of MDR-TB. However, three health-care workers and several key informant respondents mentioned fears of potential MDR-TB transmission with home-based care and highlighted the need for isolation of patients during the initial phase of treatment, either in a special tukul at home or in a local isolation ward. Respondents mentioned perceiving hospital as being an environment that poses greater risk for catching other infections via nosocomial transmission and the majority of respondents felt the home environment would be more protective of patients’ health in this regard.
Community members in general were positive about the idea of patients being treated at home: the majority of women and young women in two focus groups thought home was the best place for people with MDR-TB to be treated; and nearly half the young men in another focus group preferred home - the other half were either unsure or said they would prefer hospital due to perceptions that treatment would be more likely to be delivered on time. No participants of these community focus group discussions mentioned a fear of MDR-TB transmission to themselves associated with patients being treated at home within the community.
‘Actually because when you see the signs and symptoms of HIV compared with that of tuberculosis, normally they are similar… loss of weight, the appearance of the face, the hair, moves similar to that of HIV.’ Focus group discussion 04 – young males
‘After the sensitisation within here there is now nothing, people are living normal lives, they are supporting us and others with ideas, we can chat freely.’ Family member 01
Inadequate treatment of DS-TB
‘I used to go to the hospital and there would be no drugs’ Patient 01
‘I was taking expired drugs for a very good period’ Patient 06
Several health-care workers echoed these views on treatment availability for DS-TB, mentioning lack of consistency in drug supplies, low drug stocks and periods when there were no drugs available.
‘It is an issue of adherence, they stop start stop start if they feel better.’ Key informant 02
Respondents’ opinions on MDR-TB development in this context highlight potential issues in need of attention, including patient education to improve adherence to DS-TB treatment and improvements in drug supply.
The results show that home-based treatment and care was acceptable to patients, families, communities and health-care workers and was seen as preferable to hospital-based care by most respondents in all groups, including by all interviewed patients and family members. Home-based care was also viewed as safe, conducive to recovery, facilitating psychosocial support and allowing more free time and earning potential for patients and caretakers. While some health-care workers were concerned about infection transmission risks with home-based care, patients were instead concerned about hospital-acquired infections. In addition to MDR-TB treatment, MSF provided information on MDR-TB and infection control to the patient and their extended household, including education around modes of transmission. Patients were isolated in a separate Tukul (hut) within the home during the initial phase of treatment, while they were sputum positive, the logistics of which were supported by MSF. Home visits were conducted by MSF medical staff and a counsellor, who paid attention to the patient’s experience as well as perceptions of the family. These factors would have influenced the results with regards to assertions around MDR-TB transmission.
Most participants identified MDR-TB as having developed from DS-TB treatment interruptions. That certain health-care workers and key informants also associated MDR development with DS-TB patient adherence is a crucial point which warrants further investigation into the treatment for DS-TB and specific action targeting adherence to this treatment.
The need for a treatment strategy in Uganda, which rapidly and adequately treats MDR-TB and HIV has been highlighted elsewhere, with one study finding the retreatment approach to TB to be unsatisfactory . Our study is the first to assess the acceptability of a model of home-based treatment and care for MDR-TB for patients and staff. However, this is complemented by several studies examining community-based models of treatment for DS-TB and MDR-TB in multiple settings, including Uganda. These show community or home-based treatment to be effective, feasible and safe [6–8] as well as supportive of adherence .
Qualitative research exploring patients’ responses to various models of MDR-TB treatment is lacking, and thus our study provides an insight into a patient-centred approach to assessing this model of treatment and care. In qualitative research examining the DOTS approach for DS-TB, support and treatment delivery that were patient-centred, rather than enforced via inspectorial observation, resulted in higher treatment uptake and adherence  as did the addition of social and psychological support . Other research has highlighted the need for treatment that goes beyond provision of anti-TB drugs to include care and support delivered via ground-up models  and a focus on patient contacts as well as patients themselves . These findings are in line with Component 5 of the Stop TB Strategy, outlining the need for patient and community involvement in TB care to achieve sustainable and effective TB initiatives .
Health and treatment outcomes have been shown to be influenced by the psychosocial and economic aspects of treatment and care for MDR-TB . In our study, respondents described factors relating to health and treatment outcomes as being enhanced through home-based care. Socioeconomic access barriers were mentioned in association with hospital-based but not home-based care. A similar finding was noted in qualitative research examining the DOTS approach for DS-TB, with barriers described including patients not being able to undertake treatment due to cost of transport to services and loss of earnings through inability to work . In our study, respondents noted that home-based care allowed psychological support from family members and social contact with friends and community members. They also described close relationships with MSF staff including counsellors and the health-care workers who directly observed treatment. These factors were seen to facilitate the treatment process, giving strength of mind and positivity to patients and encouraging them with adherence. Respondents did not mention any patients experiencing difficulties with adherence, however this topic was not examined specifically and thus conclusions cannot be drawn. All MDR-TB patients interviewed mentioned the importance of being able to have free time for other activities.
Our study showed that some health-care workers were concerned about the risk of transmission of MDR-TB if patients were treated at home, while conversely patients were concerned about the risk of catching other infections in hospital. The perceptions of the patients reflect findings that there are fewer opportunities for transmission of other infections with home-based MDR-TB treatment and care . Further research is required to examine secondary transmission of MDR-TB in both hospital and community treatment models. Our results demonstrated that fears of MDR-TB infections lay with health-care professionals rather than with health-care receivers, which warrants further investigation into how such fears might guide health-care worker practice and whether these fears are warranted. This finding also calls for programmatic attention to ensure adequate training of staff on the risks of nosocomial transmission and transmission prevention measures used in home-based treatment settings.
Respondents outlined the existence of weaknesses within current national DS-TB health services including the provision of expired drugs, lack of drug availability and drug stock outs, lack of staff availability for refill dispensing, and lack of support and information to encourage patients to adhere to treatment. There is need for adequate treatment provision for DS-TB in order to prevent the selection of naturally occurring mutations that cause MDR-TB to develop . Our results highlighted the importance of a strengthened drug supply line to villages, since the role of supply interruptions for TB medication in development of MDR resistance was acknowledged by both patients and medical staff. The negative effects of drug stock outs have been shown in HIV, though there is a dearth of research in this area for TB . To address the issue of interrupted drug supply lines, MSF has trained suppliers and relevant Ministry of Health staff in medical supply ordering processes.
In July 2012, Uganda’s Ministry of Health began rolling out its first national treatment programme for MDR-TB, which aims to treat around 250 already confirmed cases. The proposed treatment strategy involves initial hospitalisation followed by ambulatory care with patients being monitored by regional health centres and treatment delivered at the community level by village health teams. Our findings on patients’ experiences of home-based care could be used to contribute to adaptation of treatment approach strategy at national level.
Our study design was explorative and the findings are not generaliseable to all contexts and settings. However, our work highlights issues likely to be relevant to many, particularly those with a similarly high proportion of rurally situated patients with low socioeconomic status; and is supported by findings that ambulatory or community-based care is feasible and effective. Analysis of participant accounts is interpretative and involves the “positioned” researcher . Reflexivity about the influence of the researcher on shaping the data was ensured through awareness of potential researcher biases and analysing verbatim transcriptions word-for-word to avoid interpretation of meaning by the researcher. Coding and emergent themes were also checked by a second researcher to minimise potential bias. The principal investigator is a young white British female; the power dynamic of researcher and participant has been acknowledged throughout data collection and analysis and has been minimised by the fact that the principal investigator had no responsibility for programme management or patient care and was an outsider to routine programme activities.
The design of this study precluded collection of data on resistance patterns and increase in vulnerability to the development of resistance. While it demonstrates that fears of barriers to treatment created by stigma and community rejection are unfounded, this present proof of acceptability to patients and communities is not in itself adequate to demonstrate that home-based care for MDR-TB is equally effective or superior to hospital-based care as we have not assessed the effect of the extension of current supply lines for MDR-TB medications that would be needed in an expanded home-based care model.
In a rural setting in Uganda, home-based treatment and care for MDR-TB was found to be preferred by patients and staff to hospital-based care for three main reasons: it was seen as being more conducive to patient recovery, it enabled enhanced psychosocial support and it allowed more free time for patients and caretakers to conduct other activities. Patients and staff viewed home-based treatment and care to be patient-centred, accessible, acceptable and feasible in this setting. Assertions on nosocomial transmission and drug supply interruptions highlight the need for improved training on infection control for health-care workers.
It is essential not to overlook the importance of reliable drug supply lines and buffer stock management for DS and MDR-TB programmes, with contingency planning in case of failure of supply lines. Studies to research this issue are currently lacking but are urgently needed to inform programming decisions and donor choices.
This study adheres to the RATS Guidelines on qualitative research.
Shona Horter thanks the Parkes Foundation for a grant assisting her to carry out this work. The funders had no role in the design, collection, analysis or interpretation of data or in writing the manuscript or on its submission for publication. We thank Sarah Venis for editing assistance with the manuscript.
- WHO: Global Tuberculosis Report 2012. 2012, Geneva: WHOGoogle Scholar
- WHO: Multidrug and Extensively Drug-Resistant TB (M/XDR-TB): 2010 Global Report on Surveillance and Response. 2010, Geneva: WHOGoogle Scholar
- Fitzpatrick C, Floyd K: A systematic review of the cost and cost effectiveness of treatment for multidrug-resistant tuberculosis. Pharmacoeconomics. 2012, 30: 63-80. 10.2165/11595340-000000000-00000.View ArticlePubMedGoogle Scholar
- Smart T: Decentralised, patient-centred models of delivering treatment and palliative care for people with M/XDR-TB. HATIP. 2010, 166: 2-9. Available: https://www.aidsmap.com/pdf/HATIP-166-October-8th-2010/page/1520450/ Accessed Jan 28, 2011Google Scholar
- WHO: Global Tuberculosis Control 2011. 2011, Geneva: WHOGoogle Scholar
- Mitnick C, Bayons J, Palacios E, Shin S, Furin J, Alcantara F, Sanchez E, Sarria M, Becerra M, Smith Fawzi M, Kapiga S, Neuberg D, Maguire J, Yong Kim J, Farmer P: Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru. NEJM. 2003, 348: 119-128. 10.1056/NEJMoa022928.View ArticlePubMedGoogle Scholar
- Luyirika E, Nsobya H, Batamwita R, Busingye P, Musoke W, Nabiddo L, Karamagi Y, Mukasa B: A home-based approach to managing multi-drug resistant tuberculosis in Uganda: a case report. AIDS Res Ther. 2012, 9: 12-10.1186/1742-6405-9-12.View ArticlePubMedPubMed CentralGoogle Scholar
- Heller T, Lessells R, Wallrauch C, Barnighausen T, Cooke G, Mhlongo L, Master I, Newell M: Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa. Int J Tuberc Lung Dis. 2010, 14: 420-426.PubMedGoogle Scholar
- Chalco K, Wu D, Mestanza L, Munoz M, Llaro K, Guerra D, Palacios E, Furin J, Shin S, Sapag R: Nurses as providers of emotional support to patients with MDR-TB. Int Nurs Rev. 2006, 53: 253-260. 10.1111/j.1466-7657.2006.00490.x.View ArticlePubMedGoogle Scholar
- Nathanson E, Lambregts-van Weezenbeek C, Rich M, Gupta R, Bayona J, Blondal K, Caminero J, Cegielski P, Danilovits M, Espinal M, Hollo V, Jaramillo E, Leimane V, Mitnick C, Mukherjee J, Nunn P, Pasechnikov A, Tupasi T, Wells C, Raviglione M: Multidrug-resistant tuberculosis management in resource-limited settings. Emerg Infect Dis. 2006, 12: 1389-1397. 10.3201/eid1209.051618.View ArticlePubMedPubMed CentralGoogle Scholar
- WHO: Treatment of Tuberculosis Guidelines. 2010, Geneva: WHO, 4Google Scholar
- WHO: Guidelines for the Programmatic Management of Drug-Resistant Tuberculosis: 2011 Update. 2011, Geneva: WHOGoogle Scholar
- Furin J, Bayona J, Becerra M, Farmer P, Golubkov A, Hurtado R, Joseph JK, Keshavjee S, Ponomarenko O, Rich M, Shin S: Programmatic management of multidrug-resistant tuberculosis: models from three countries. Int J Tuberc Lung Dis. e-publication ahead of print 8 June 2011. doi:10.5588/ijtld.10.0591Google Scholar
- Palacios E, Guerra D, Llaro K, Chalco K, Sapag R, Furin J: The role of the nurse in the community-based treatment of multidrug-resistant tuberculosis (MDR-TB). Int J Tuberc Lung Dis. 2003, 7: 343-346.PubMedGoogle Scholar
- World Bank: Uganda at a glance – World Bank. Available: devdata.worldbank.org/AAG/uga_aag.pdf Accessed October 26, 2012Google Scholar
- Kiwanuka SN, Ekirapa EK, Peterson S, Okui O, Hafizur Rahman M, Peters D, Pariyo GW: Access to and utilisation of health services for the poor in Uganda: a systematic review of available evidence. Trans R Soc Trop Med Hyg. 2008, 102 (11): 1067-1074. 10.1016/j.trstmh.2008.04.023.View ArticlePubMedGoogle Scholar
- Shoaib M, Velivela K, Sharmin S, Seshadri P, Kasozi S, Casas EC, Verputten M: A decentralised, community-based model of care for DR-TB in northern Uganda. Poster presented at MSF Scientific Day. 2012, Available: http://issuu.com/msfuk/docs/verputten_uganda_drtb/1 Accessed Oct 23, 2012Google Scholar
- WHO: The Stop TB Strategy: Building on and Enhancing DOTS to Meet the TB-Related Millennium Development Goals. 2006, Geneva: WHOGoogle Scholar
- Green J, Thorogood N: Qualitative Methods for Health Research. 2009, London: Sage PublicationsGoogle Scholar
- Basit T: Manual or electronic? The role of coding in qualitative data analysis. Educ Res. 2003, 45: 143-154. 10.1080/0013188032000133548.View ArticleGoogle Scholar
- Bradley E, Curry L, Devers K: Qualitative data analysis for health services research: developing taxonomy, themes and theory. Health Serv Res. 2007, 42: 1758-1772. 10.1111/j.1475-6773.2006.00684.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Jones-López EC, Ayakaka I, Levin J, Reilly N, Mumbowa F, Dryden-Peterson S, Nyakoojo G, Fennelly K, Temple B, Nakubulwa S, Joloba ML, Okwera A, Eisenach KD, McNerney R, Elliott AM, Ellner JJ, Smith PG, Mugerwa RD: Effectiveness of the standard WHO recommended retreatment regimen (Category II) for tuberculosis in Kampala, Uganda: a prospective cohort study. PLoS Med. 2011, 8: e1000427-10.1371/journal.pmed.1000427.View ArticlePubMedPubMed CentralGoogle Scholar
- Gelmanova IY, Taran DV, Mishustin SP, Golubkov AA, Solovyova AV, Keshavjee S: ‘Sputnik’: a programmatic approach to improve tuberculosis treatment adherence and outcome among defaulters. Int J Tuberc Lung Dis. 2011, 15: 1373-1379. 10.5588/ijtld.10.0531.View ArticlePubMedGoogle Scholar
- Noyes J, Popay J: Directly observed therapy and tuberculosis: how can a systematic review of qualitative research contribute to improving services? A qualitative meta-synthesis. J Adv Nurs. 2007, 57: 227-243. 10.1111/j.1365-2648.2006.04092.x.View ArticlePubMedGoogle Scholar
- Koch E: Tuberculosis is a threshold: the making of a social disease in post-Soviet Georgia. Med Anthropol. 2013, 32: 309-324. 10.1080/01459740.2012.751384.View ArticlePubMedGoogle Scholar
- Cavalcante SC, Durovni B, Barnes GL, Souza FB, Silva RF, Barroso PF, Mohan CI, Miller A, Golub JE, Chaisson RE: Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil. Int J Tuberc Lung Dis. 2010, 14: 203-209.PubMedPubMed CentralGoogle Scholar
- Temple B, Ayakaka I, Ogwang S, Nabanjja H, Kayes S, Nakubulwa S, Worodria W, Levin J, Joloba M, Okwera A, Eisenach KD, McNerney R, Elliott AM, Smith PG, Mugerwa RD, Ellner JJ, Jones-López EC: Rate and amplification of drug resistance among previously-treated patients with tuberculosis in Kampala, Uganda. Clin Infect Dis. 2008, 47: 1126-1134. 10.1086/592252.View ArticlePubMedPubMed CentralGoogle Scholar
- Pasquet A, Messou E, Gabillard D, Minga A, Depoulosky A, Deuffic-Burban D, Losina E, Freedberg KA, Danel C, Anglaret X, Yazdanpanah Y: Impact of drug stock-outs on death and retention to care among HIV-infected patients on combination antiretroviral therapy in Abidjan, Cote d’Ivoire. PLoS One. 2010, 5: e13414-10.1371/journal.pone.0013414.View ArticlePubMedPubMed CentralGoogle Scholar
- Malterud K: Qualitative research: standards, challenges and guidelines. Lancet. 2001, 358: 483-488. 10.1016/S0140-6736(01)05627-6.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://0-www.biomedcentral.com.brum.beds.ac.uk/1472-6963/14/81/prepub
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