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Table 3 Health state, event, drug acquisition and consumable costs used in the analysis, expressed in 2013 Euros (€)

From: Cost-effectiveness analysis of liraglutide versus sitagliptin or exenatide in patients with inadequately controlled Type 2 diabetes on oral antidiabetic drugs in Greece

Cost description

Costs (€)

Reference

Management costs

  

Annual cost of statins

147.97

Experts opinion & Drug price bulletin [15]

Annual cost of aspirin

14.41

Experts opinion & Drug price bulletin [15]

Annual cost of ACE inhibitors

78.32

Experts opinion & Drug price bulletin [15]

Annual cost of screening for microalbuminuria

8.66

Government Gazette*

Annual cost of screening for gross proteinuria

8.66

Government Gazette*

Annual cost of stopping ACEIs due to side effects

15.00

Experts opinion

Annual cost of eye screening

10.00

Experts opinion & Government Gazette

Annual cost of foot screening program

10.00

Experts opinion & Government Gazette

Annual cost of non-standard ulcer treatment

0.00

This is a patient’s expenditure

Annual cost of anti-depression treatment

154.50

Experts opinion & Drug price bulletin [15]

Annual cost of screening for depression

10.00

Experts opinion & Government Gazette

Direct costs of cardiovascular complications

 

Myocardial infarction, 1st year of event

6000

G. Kourlaba et al. [19]

Myocardial infarction, each subsequent year

1964

G. Kourlaba et al. [19]

Angina, 1st year of event

3613

National School of Public Health (data on file)

Angina, each subsequent year

1197

National School of Public Health (data on file)

Congestive heart failure, year of onset

3910

National School of Public Health (data on file)

Congestive heart failure, each subsequent year

1398

National School of Public Health (data on file)

Stroke, 1st year of event

4406

G. Kourlaba et al. [19]

Stroke, each subsequent year

1976

G. Kourlaba et al. [19]

Stroke, death within 30 days

3675

Government Gazette (DRG-code: N30Mα) & G. Kourlaba et al. [19]

Peripheral vascular disease, year of onset

5713

G. Kourlaba et al. [20]

Peripheral vascular disease, each subsequent year

1426

G. Kourlaba et al. [20]

Direct costs of renal complications

  

Hemodialysis, first year

40352

D. Kaitelidou et al. & K. Souliotis et al. [17, 18]

Hemodialysis, each subsequent year

40352

Assumed equal with 1st year hemodialysis cost

Peritoneal dialysis, first year

46156

Experts opinion & Government Gazette (DRGs-code: Υ28Α and Y02M)

Peritoneal dialysis, each subsequent year

43656

Experts opinion & Government Gazette (DRG-code: Υ28Α)

Kidney transplant, first year

18489

S. Sidiropoulos [21]

Kidney transplant, each subsequent year

5400

K. Souliotis et al. [17]

Direct costs of acute events

  

Major hypoglycaemic event

700

National School of Public Health (data on file)

Minor hypoglycaemic event

250

National School of Public Health (data on file)

Direct costs of eye disease

  

Cost of laser treatment

731

Government Gazette† (DRG-code: O03A)

Cost of cataract operation

933

Government Gazette† (DRG-code: O15A)

Cost following cataract operation

59

Experts opinion & Drug price bulletin [15]

Cost of blindness in year of onset

11280

Experts opinion & K. Athanasakis et al. [16]

Cost of blindness in subsequent years

6200

Experts opinion & K. Athanasakis et al. [16]

Direct costs of neuropathy, foot ulcer and amputation

Neuropathy, year of onset

1120

Experts opinion, Drug price bulletin [15] & Government Gazette¶‡

Neuropathy, each subsequent year

1120

Experts opinion, Drug price bulletin [15] & Government Gazette¶‡

Amputation, year of event

6629

Government Gazette† (DRG-code: K11M)

Amputation, prosthesis

1150

Government Gazette

Gangrene treatment

5282

Experts opinion, Drug price bulletin [15] & Government Gazette (DRGs-code: K11M & K13M)

Cost of infected ulcer treatment

2835

Experts opinion, Drug price bulletin [15] & Government Gazette¶† (DRG-code: Δ20Μ)

Cost of uninfected ulcer treatment

387

Experts opinion, Drug price bulletin [15] & Government Gazette

Cost after healed ulcer

120

Experts opinion & Government Gazette

Cost of healed ulcer (history of amputation)

1471

Government Gazette† (DRG-code: Δ20Χ)

Costs of interventions

 

Drug price bulletin [15]

Liraglutide (1.2 mg)

3.44 per day

 

Liraglutide (1.8 mg)

5.16 per day

 

Sitagliptin

1.30 per day

 

Exenatide BID

2.84 per day

 

Metformin

0.11 per day

 

Sulphonylurea (Glimepiride)

0.14 per day

 

Basal insulin (Glargine)

1.38 per day

 

Consumable costs

 

Government Gazette#

Needles for injectable drugs

0.17 per needle

 

SMBG test strips

0.43 per strip

 

SMBG lancets

0.09 per lancet

 
  1. *Reimbursement for screening tests (Ministerial Decree, Α4 /2878/4-6-1992).
  2. Reimbursement for a doctor’s office visit (Presidential Decree, FEK 262A’/16-12-2011).
  3. Reimbursement for diagnosis-related groups (Common Ministerial Decree, FEK 946B’/27-3-2012).
  4. EOPYY Health Provision Policy Regulation (Common Ministerial Decree, FEK 3054B’/18-11-2012).
  5. #Reimbursement for consumables (Common Ministerial Decree, FEK 1561B’/21-06-2013).
  6. ACE = Angiotensin-converting enzyme; SMBG = Self-monitoring blood glucose, DRG = Diagnosis-related group.