Updated cost-of-care estimates for commercially insured patients with multiple sclerosis: retrospective observational analysis of medical and pharmacy claims data

Table 3 MS charges ^a by presence of selected disease sequelae in 2011

Condition	Diagnosis code^b	N	Prevalence	Mean [SD] charges ($)	PValue
Abnormality of gait	781.2	1,196	7.5	48,361 [55,472]	<0.001
Ataxia	781.3	347	2.2	48,605 [63,100]	<0.001
Burning, numbness, tingling sensations	782.0	1,566	9.8	33,648 [45,273]	<0.001
Convulsions^c	780.3	0	0.0	---	---
Depression^d	296.2, 296.3, 300.4, 311; DRG = 881	1,255	7.9	42,831 [51,693]	<0.001
Fecal incontinence	787.6	0	0.0	---	---
Fibromyalgia/myalgia and myositis	729.1	399	2.5	38,319 [63,441]	<0.001
Malaise and fatigue^c	780.7	2,235	14.1	39,948 [48,435]	<0.001
Optic neuritis	341.0	38	0.2	82,134 [98,886]	0.001
Spasms	781.0	412	2.6	48,337 [52,475]	<0.001
Trigeminal neuralgia	350.1	150	0.9	38,165 [46,506]	0.002
Urinary incontinence^c	788.3	339	2.1	47,885 [49,226]	<0.001
Voice disturbance^c	784.4, 784.5	23	0.1	44,973 [57,858]	0.140

^aSum of the charges for (1) medical claims with an MS diagnosis (ICD-9-CM = 340.xx in any diagnosis field or a DRG code for MS and cerebellar ataxia [DRG = 058, 059, or 060]) plus (2) medical or pharmacy claims indicating a DMD (Table 1).
^bICD-9-CM coding except where otherwise specified.
^cIdentified by Prescott et al. using a combination of ICD-9-CM codes and ETG coding [10].
^dIdentified by Prescott et al. using only ETG coding [10].
DMD = disease-modifying drug; DRG = Diagnosis-Related Group; ETG = Episode Treatment Group; ICD-9-CM = International Classification of Diseases, Ninth Revision, Clinical Modification; MS = multiple sclerosis; SD = standard deviation.

ISSN: 1472-6963