Table 1 Characteristics of patients treated with febrile neutropenia
From: Time to antibiotics and outcomes in cancer patients with febrile neutropenia
Clinical variables | Total patients N = 105 (%) | High risk patients N = 37 (%) | Low risk patients N = 68 (%) | P value |
|---|---|---|---|---|
Median age yrs | 60 (18–89) | 66 (46–86) | 55 (18–89) | 0.058 |
Age over 65 | 36 (34) | 22 (60) | 14 (21) | <0.001 |
Male | 43 (41) | 21 (57) | 22 (32) | 0.01 |
MASCC score | 21 ± 2.5 | 18 ± 1.3 | 23 ± 1.5 | 0.15 |
Comorbid illness | 52 (49) | 32 (86) | 20 (29) | <0.001 |
Diabetes mellitus | 12 (11) | 8 (22) | 4 (6) | 0.02 |
Chronic renal failure | 4 (4) | 3 (8) | 1 (2) | 0.12 |
Hematological malignancies | 46 (44) | 19 (51) | 27 (40) | 0.17 |
Advanced disease | 63 (60) | 24 (65) | 39 (57) | 0.29 |
Prophylactic filgrastim & or antibiotics | 50 (48) | 17 (46) | 33 (49) | 0.48 |
Mean SBP mmHg | 123 ± 22 | 120 ± 21 | 124 ± 23 | 0.71 |
Mean heart rate bpm | 105 ± 20 | 101 ± 17 | 107 ± 21 | 0.97 |
Mean O2 saturation% | 97 ± 2 | 97 ± 2 | 97 ± 2 | 0.76 |
Mean WBC 109/l | 0.83 ± 2.8 | 1.5 ± 4.8 | 0.99 ± 0.69 | 0.056 |
Mean ANC 109/l | 0.21 ± 0.23 | 0.21 ± 0.18 | 0.21 ± 0.25 | 0.08 |
Mean hemoglobin g/L | 98 ± 21 | 97 ± 18 | 102 ± 23 | 0.20 |
Mean platelet count 109/l | 136 ± 102 | 127 ± 106 | 156 ± 98 | 0.004 |
Mean serum sodium mEq/L | 135 ± 3 | 134 ± 3 | 134 ± 4 | 0.60 |
Mean serum creatinine μmol/L | 69 ± 36 | 99 ± 50 | 68 ± 16 | <0.001 |
Mean BUN mmol/L | 5 ± 4.2 | 8.6 ± 5.3 | 4.7 ± 2.6 | <0.001 |
Median TAA hrs (range) | 2.5 (0.03-50) | 3 (0.22-19) | 2.5 (0.03-50) | 0.16 |