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Table 6 Estimated preference weights and Willingness to Pay (WTP) in a propensity score matched subset of the public and patients

From: Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE)

 

The public, scenario A

 

(N = 83)

patients, scenario A

 

(N = 38)

P-value for difference

 

Coefficient (s.e.)

OR

MWTP

Coefficient (s.e.)

OR

MWTP

 

Untreated responders &

       

   5%

0.248 (0.0687)**

1.58

2,658

0.8794 (0.1068)**

5.23

12,820

<.0001

   20%

0.0528 (0.0676)

1.30

1517

0.0442 (0.1068)

2.27

6,346

0.6084

   35%

−0.0942 (0.0702)

1.12

657

−0.1492 (0.1133)

1.87

4,847

0.6582

   50%

−0.2066

1

Ref

−0.7744

1

Ref

 

Unnecessary treatment of non-responders †

       

   5%

0.1867 (0.0679)**

1.39

1,919

0.1083 (0.1083)

1.59

3,580

0.9663

   20%

0.0134 (0.0697)

1.17

906

0.2391 (0.1112)*

1.81

4,594

0.1598

   35%

−0.0586 (0.0683)

1.09

485

0.0062 (0.1088)

1.43

2,789

0.657

   50%

−0.1415

1

Ref

−0.3526

1

Ref

 

Severity of side effects

       

   Mild

0.2712 (0.0524)**

2.10

4,327

0.3084 (0.0839)**

2.09

5,716

0.7

   Moderate

0.1976 (0.053)**

1.95

3,897

0.1206 (0.0871)

1.73

4,260

0.3008

   Severe

−0.4688

1

Ref

−0.4290

1

Ref

 

Likelihood of side effects

       

   5%

0.2645 (0.0521)**

1.65

2,937

0.2735 (0.0838)*

1.60

3,650

0.8119

   50%

−0.0267 (0.0529)

1.24

1,235

−0.0762 (0.0864)

1.13

939

0.5678

   95%

−0.2378

1

Ref

−0.1973

1

Ref

 

Genetic test turnaround time

       

   2 days

0.1673 (0.0531)**

1.40

1,978

0.0174 (0.087)

1.15

1,117

0.2467

   7 days

0.0036 (0.0521)

1.19

1,021

0.1093 (0.0857)

1.27

1,829

0.5259

   12 days

−0.1709

1

Ref

−0.1267

1

Ref

 

Genetic test procedure

       

   Mouth swab

0.2591 (0.0783)**

1.75

3,258

0.3918 (0.1239)*

2.43

6,881

0.4303

   Blood sample

0.3382 (0.0825)**

1.89

3,720

0.1168 (0.1322)

1.85

4,750

0.2508

   Tumor biopsy

−0.04 (0.0828)

1.29

1,509

−0.0829 (0.1342)

1.51

3,202

0.7787

   Bone marrow biopsy

−0.2593 (0.081)**

1.04

226

0.0702 (0.1286)

1.76

4,388

0.1121

   Liver biopsy

−0.2980

1

Ref

−0.4959

1

Ref

 

Neither (No test)

−1.0346 (0.1037)**

0.36

−6,050

−0.1185 (0.1382)

0.89

−919

0.0002

Genetic test cost

−0.00017 (0.00007)*

 

Ref

−0.00013 (0.00012)

 

Ref

0.1901

   McFadden’s LRI

0.20

      

   Adjusted Estrella

0.35

      

   Log-likelihood Ratio

832.8

      

   AIC

3493

      

   Schwartz Criterion

3694

      
  1. ** p-value < 0.01; * p-value < 0.05.
  2. &1-Sensitivity.
  3. †1-specificity.