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Table 5 Estimated preference weights and Willingness to Pay (WTP) in samples from the public

From: Genomic testing to determine drug response: measuring preferences of the public and patients using Discrete Choice Experiment (DCE)

 

The public, scenario A

(N = 533)

 

The public, scenario B

(N = 525)

 

P-value for difference

 

Coefficient (s.e.)

OR

MWTP

Coefficient (s.e.)

OR

MWTP

 

Untreated responders &

       

   5%

0.1748 (0.0266)**

1.41

1,331

0.2577 (0.0270)**

1.65

1,344

0.0241

   20%

0.0367 (0.0265)

1.23

796

0.0324 (0.0274)

1.32

740

0.8487

   35%

−0.0429 (0.0276)

1.13

487

−0.0465 (0.0285)

1.22

528

0.9315

   50%

−0.1686 (0.0466)

1

Ref

−0.2436 (0.0479)**

1

Ref

 

Unnecessary treatment of non-responders †

       

   5%

0.1008 (0.0268)**

1.24

827

0.2452 (0.0270)**

1.50

1,080

0.0004

   20%

0.0065 (0.0274)

1.13

461

0.0377 (0.0288)

1.22

524

0.6691

   35%

0.0051 (0.0272)

1.12

456

−0.1251 (0.0281)**

1.03

88

0.0115

   50%

−0.1124 (0.0470)

1

Ref

−0.1578 (0.0485)**

1

Ref

 

Severity of side effects

       

   Mild

0.3319 (0.0205)**

2.10

2,882

0.3295 (0.0211)**

2.24

2,165

0.3838

   Moderate

0.0798 (0.0210)**

1.63

1,905

0.1484 (0.0217)**

1.87

1,679

0.0621

   Severe

−0.4117 (0.0293)**

1

Ref

−0.4779 (0.0303)**

1

Ref

 

Likelihood of side effects

       

   5%

0.2490 (0.0204)**

1.62

1,861

0.2622 (0.0213)**

1.75

1,497

0.2245

   50%

−0.0179 (0.0209)

1.24

826

0.0340 (0.0214)

1.39

885

0.2261

   95%

−0.2311 (0.0292)**

1

Ref

−0.2962 (0.0302)**

1

Ref

 

Genetic test turnaround time

       

   2 days

0.1213 (0.0210)**

1.26

911

0.1266 (0.213)**

1.27

650

0.4533

   7 days

−0.0076 (0.0208)

1.11

411

−0.0107 (0.0218)

1.11

282

0.5396

   12 days

−0.1137 (0.0296)**

1

Ref

−0.1159 (0.0305)**

1

Ref

 

Genetic test procedure

       

   Mouth swab

0.2962 (0.0304)**

1.75

2,162

0.3045 (0.0311)**

1.73

1,474

0.9942

   Blood sample

0.2863 (0.0320)**

1.73

2,124

0.3882 (0.0332)**

1.88

1,698

0.5738

   Tumor biopsy

−0.0416 (0.0326)

1.25

853

−0.0809 (0.0332)**

1.18

440

0.8152

   Bone marrow biopsy

−0.2792 (0.0321)**

0.98

−68

−0.3666 (0.0339)**

0.89

−325

0.6879

   Liver biopsy

−0.2617 (0.0636)**

1

Ref

−0.2452 (0.0675)**

1

Ref

 

Neither (No test)

−0.6323 (0.0379)**

0.53

−2,451

−0.4967 (0.0389)**

0.61

−1,332

0.0169

Genetic test cost

−0.00026 (0.00003)**

 

Ref

−0.00037 (0.00003)**

 

Ref

0.0091

   McFadden’s LRI

0.17

      

   Adjusted Estrella

0.33

      

   Log-likelihood Ratio

6216.5

      

   AIC

31050

      

   Schwartz Criterion

31329

      
  1. ** p-value < 0.01.
  2. &1-Sensitivity.
  3. †1-specificity.