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Effects of proactive population-based nephrologist oversight on progression of chronic kidney disease: a retrospective control analysis
© Lee et al.; licensee BioMed Central Ltd. 2012
Received: 18 April 2012
Accepted: 1 August 2012
Published: 15 August 2012
Benefits of early nephrology care are well-established, but as many as 40% of U.S. patients with end-stage renal disease (ESRD) do not see a nephrologist before its onset. Our objective was to evaluate the effect of proactive, population-based nephrologist oversight (PPNO) on chronic kidney disease (CKD) progression.
Retrospective control analysis of Kaiser Permanente Hawaii members with CKD using propensity score matching methods. We matched 2,938 control and case pairs of individuals with stage 3a CKD for the pre-PPNO period (2001–2004) and post-PPNO period (2005–2008) that were similar in other characteristics: age, gender, and the presence of diabetes and hypertension. After three years, we classified the stage outcomes for all individuals. We assessed the PPNO effect across all stages of progression with a χ 2- test. We used the z-score test to assess the proportional differences in progression within a stage.
The progression within the post-PPNO period was less severe and significantly different from the pre-PPNO period (p = 0.027). Within the stages, there were 2.6% more individuals remaining in 3a in the post-period (95% confidence interval [CI], 1.5% to 3.8%; P value < 0.00001). Progression from 3a to 3b was 2.2% less in the post-period (95% [CI], 0.7% to 3.6%; P value = 0.0017), 3a to 4/5 was 0.2% less (95% CI, 0.0% to 0.87%; P value = 0.26), and 3a to ESRD was 0.24% less (95% CI, 0.0% to 0.66%, P value = 0.10).
Proactive, population-based nephrologist oversight was associated with a statistically significant decrease in progression. With enabling health information technology, risk stratification and targeted intervention by collaborative primary and specialty care achieves population-level care improvements. This model may be applicable to other chronic conditions.
In tandem with increasing rates of obesity and diabetes, the prevalence of chronic kidney disease (CKD) continues to rise. Recent estimates suggest that 11.5% to 14.5% of the U.S. adult population has early- to late-stage CKD [1–3]. Benefits of early nephrology care for CKD are well-established: slowed progression of disease, better preparation for renal replacement therapy (RRT), greater likelihood of outpatient hemodialysis initiation, and reduced mortality [4–6]. Yet as many as 40% of patients in the United States do not see a nephrologist before the onset of end-stage renal disease (ESRD) , and fewer than 25% have been followed by a nephrologist for at least a year before end-stage disease .
A new model of care providing proactive population-based nephrologist oversight (PPNO) reduces late referrals and increases the proportion of patients starting hemodialysis with a mature arteriovenous fistula and as outpatients . The model consists of risk stratifying a CKD population and providing unsolicited nephrologist consultations to primary care physicians regarding individual patients, enabled by an integrated electronic health record (EHR). Nephrologists collaborate with primary care colleagues, helping primary care providers manage the patients they can and refer those patients who need specialist care. Our objective in this quality improvement project was to assess the effect of PPNO on CKD progression.
Kaiser Permanente Hawaii (KPHI) is one of eight regions of Kaiser Permanente, one of the United States’ leading health care providers and not-for-profit health plans with 9.0 million members in nine states and the District of Columbia. Kaiser Permanente addresses all health care needs for adults and children, including preventive, routine, specialty, emergency, and inpatient care, ancillary testing, pharmacy and rehabilitative services, and home care and functions as an accountable care organization . KPHI has 224,000 members; 58 family practice physicians and 52 internists refer CKD patients to a specialty division with six nephrologists. KPHI has an integrated electronic health record (EHR), KP HealthConnectTM, providing comprehensive clinical information on all members.
Using the EHR, we identified all KPHI members during 2001–2010 who had at least two recorded serum creatinine levels a minimum of three months apart identifying different CKD stages and were at stage 3a CKD or higher. From this dataset, we excluded patients with serum creatinine patterns suggesting acute kidney injury: a decline in function within 14 days of a previous creatinine level followed by reversion to a previous higher level within 90 days. Patients whose renal function declined within 14 days of a previous creatinine level but who did not recover function within 90 days were included. In addition, we excluded those who had CKD or needed renal replacement therapy before 2001 and those whose CKD was diagnosed outside the KPHI system. Over the entire time period, we identifed 25,881 members with at least one stage of CKD.
Proactive, population-based nephrologist oversight
In collaboration with primary care, nephrologists (B.L. and A.L.) developed a model of proactive population-based nephrology oversight (PPNO) for CKD patients. The model addressed both patients without referrals and those referred to nephrology by primary care physicians (PCPs).
Patients without referrals
Using data extracted from the EHR, the population management nephrologist (B. L.) generated concise monthly individual profiles for all KPHI patients with CKD, presented in risk-stratified order. Stratification criteria included glomerular filtration rate (GFR) and urine protein-to-creatinine ratio. The nephrologists identified specific laboratory criteria for patients at high risk of progression to ESRD: (1) GFR < 20 ml/min/1.73 m2, (2) GFR < 40 ml/min/1.73 m2 and urine protein-to-creatinine ratio > 2; or (3) urine protein-to-creatinine ratio > 4. Laboratory criteria for low risk status were GFR ≥ 30 ml/min/1.73 m2 and <1 gram proteinuria.
Recognizing the impact of other factors, such as age and comorbid conditions, on the potential value of specialty care, the population management nephrologist reviewed comprehensive clinical information in the EHR for each high risk patient. Using clinical judgment to determine which patients would most benefit from nephrologist care, he contacted the responsible PCPs and requested those patients be referred for a nephrology visit.
For patients at low risk of progression, the nephrologist proactively provided electronic consultations to PCPs to improve CKD management, again using comprehensive information in the EHR. For example, the nephrologist advised primary care providers about maximal angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker pharmacotherapy for patients with overt proteinuria and uncontrolled blood pressure. Management advice was sent to PCPs via KP HealthConnect messaging. Pre-programmed blocks of text minimized the time required to generate messages.
The population management nephrologist comprehensively reviewed the EHR for all patients referred for specialty care.
If the nephrologist judged the patient to be at low risk, he contacted the referring physician about the possibility of managing the patient in the primary care setting with specific management advice and the assurance that the patient would be electronically monitored by the nephrologist.
To ensure patient safety and quality of care, the population management nephrologist flagged these patient records and looked at them first when reviewing the monthly risk-stratified profiles.
Between 2004 and 2010, the population management nephrologist reviewed the profiles of the risk-stratified CKD population, approximately 15 patients per week, reviewing the KP HealthConnect record for additional information as needed. Among the reviewed cases, many patients benefitted from improved medical management, but most did not immediately need a referral. Model-identified consultations generated about 47 referrals per year of high-risk patients. Nephrologists and primary care providers collaboratively agreed to return about 25 low-risk referrals per year to primary care with active nephrologist surveillance.
We conducted a retrospective control analysis to quantify the rate of CKD progression between stages before and after the initiation of PPNO in 2005. We defined the pre-PPNO period as January 1, 2001 to December 31, 2004 and the post-PPNO period as January 1, 2005 to December 31, 2008.
CKD staging, covariates, and data sources
We calculated an estimated GFR for each creatinine level for all patients using the Modification of Diet in Renal Disease Study equation, which incorporates creatinine level, age, gender, and race or ethnicity . We did not have race or ethnicity data, so our calculations underestimate the true GFR scores for African Americans by a factor of 1.2. However, KP Hawaii has a very small African American population (1.0%), and we assumed this bias to be negligible. For patients with estimated GFRs < 60 ml per minute per 1.73 m2, we identified the applicable stage of CKD using a modified National Kidney Foundation classification of chronic kidney disease: 45 to 59 ml per minute per 1.73 m2 (stage 3a), 30 to 44 ml per minute per 1.73 m2 (stage 3b), 15 to 29 ml per minute per 1.73 m2 (stage 4), and less than 15 ml per minute per 1.73 m2 (stage 5) . In addition, we identified patients receiving renal replacement therapy as being in ESRD.
In addition to data on CKD stage, we included the following covariates: patient demographics (age, gender, mortality), KP membership eligibility, diabetes, and hypertension. We collected serum creatinine level, patient demographics, and eligibility data from KP HealthConnect from 2001 to 2008. We collected data on diabetes and hypertension from Healthcare Employer Data and Information Set (HEDIS) data from 2001 to 2008.
We used propensity score matching to control for potential sampling bias in our assessment of the effect of PPNO on the CKD population. For the entire population, we performed data cleaning and all statistical analyses using SAS 9.1 software. We pooled the data for stages 4 and 5 to increase sample size. We summarized the pre-matched population on the covariates for the entire population.
We identified patients diagnosed with stage 3a CKD in 2001 and 2002 as the controls and followed their disease progression for three years (2001 followed in 2001, 2002, and 2003; 2002 followed in 2002, 2003, and 2004). We identified patients diagnosed in 2005 and 2006 as the cases and followed their disease progression for three years (2005 followed in 2005, 2006, and 2007; 2006 followed in 2006, 2007, and 2008). Patients were identified by the year in which they had a first creatinine level and subsequent level within 90 days that quantified them as being in stage 3a, resulting in independent samples. To account for transient fluctuations in renal function, any change in estimated GFR sustained over 90 days was counted as progression.
We then matched control and case pairs, matching randomly one-to-one without replacement for the pre- and post- PPNO groups, based on propensity scoring for age, gender, and the presence of diabetes and hypertension. We summarized the matched data on the covariates and assessed the success of matching by examining absolute differences between the covariate distribution proportions in cases and controls.
Stage outcomes were observed for each matched individual remaining in stage 3a or progressing from stage 3a to stages 3b, 4/5, and ESRD at one, two, and three year intervals in the pre- and post-PPNO periods. We tallied the final stage outcomes at the end of three years. We tested the overall effect of the PPNO on stage outcomes using the χ 2-test. Within stages, we converted the counts to proportions and assessed the differences between the pre- and post-PPNO periods with z-score tests.
The Kaiser Permanente Hawaii Institutional Review Board approved the project.
Characteristics of the analysis population and pre- and post-intervention groups for pre-matched and post-matched data
Pre-intervention N = 4,087
Post-Intervention N = 3,453
Pre-intervention N = 2,958
Post-Intervention N = 2,958
0 - 19
20 - 44
45 - 64
Differences in CKD progression on matched data
We obtained 2,958 matches between the pre- and post-PPNO data; the matches were well-balanced on the covariates (Table 1). During the pre-PPNO period, members had an average of 8.52 serum creatinine levels recorded; during the post-PPNO period, the comparable figure was 9.07 (P = 0.049). The average first estimated GFR within stage 3a was 53.37 for members in the pre-PPNO period and 53.63 in the post-period; this difference was not statistically significant (P = 0.052).
CKD stage outcomes after three years among pre- and post-PPNO groups of individuals initially identified as Stage 3a
Individuals (n = 2,958)
Individuals (n = 2,958)
3a to 3b
3a to 4/5
3a to ESRD
The overall effect of proactive population-based nephrologist oversight was statistically significant. The post-PPNO period showed less severe progression. In particular, significantly more individuals remained in stage 3a after three years. Progression from stage 3a to 3b was significantly less in the post-period and marginally statistically significantly less from stage 3a to ESRD. Our finding that appropriate population care management for patients with CKD slows the progression of disease is consistent with other observational studies .
What our project adds to the literature is a model of specialists providing population-based care that identifies and risk stratifies the entire CKD population, directing nephrology resources to patients in need of them. With enough information provided by the electronic health record about individual cases, nephrologists can determine which patients need referrals and which can be managed by primary care physicians with nephrologist surveillance.
A similar model of systematic surveillance and shared management by specialty and primary care also resulted in slowed progression of disease . However, our population was defined by having CKD, not by having received a referral for nephrology care. To the best of our knowledge, our report is the first to detail the benefits of population management by a specialty service of all CKD patients—those who have been referred for nephrologist care and those who have not.
Strengths of our report include the use of propensity score matching to control for identified confounders for which EHR data from 2001 to 2008 existed. These included diabetes, which we identified using HEDIS measures. HEDIS does not allow similar identification of members with cardiovascular disease (CVD). However, diabetes is a major risk factor for CVD , and we can reasonably assume that matching on diabetes status eliminates some of the potential confounding introduced by CVD status.
Members had more serum creatinine levels recorded during the post-PPNO period than in the pre-period. This is consistent with the goal of the program. In addition, it provides a perspective on our analysis as relatively conservative, since fewer levels during the pre-period could reflect some undetected progression from one stage to the next.
Several limitations deserve mention. Other factors may have contributed to the effects we observed. Two conferences in January 2005 and March 2007, sponsored by the KPHI nephrology department and attended by Kaiser Permanente and external physicians, focused on improving the management of patients with CKD. In addition, in June of 2007, an internal initiative was undertaken to improve hypertension management among patients with diabetes; chronic kidney disease is associated with diabetes, hypertension, or both in more than 90% of people with an estimated GFR below 60 ml per minute per 1.73 m2. Finally, the use of panel management in primary care, facilitated by the Panel Support Tool, increased during the observation period [22, 23]. The latter two factors were reflected in substantially improved HEDIS measures for calendar year 2007 (reported in 2008). Within the Medicare population, the percentage of patients with diabetes whose blood pressure was less than 140/90 mm Hg increased from 58.4% to 72.0%; the percentage whose blood pressure was less than 130/80 mm Hg increased from 36.3% to 44.3%.
We did not have comparable population data from the pre- and post-PPNO periods for corollary measures, such as angiotensin-converting enzyme inhibitor/angiotension II receptor blocker use or blood pressure control. Such data could provide more insight into the differences in progression.
Our use of an retrospective control group was an additional, albeit necessary, limitation to this evaluation. Randomizing members into PPNO or usual care was both inconsistent with the quality improvement nature of this initiative and would have reduced our ability to make statistical inferences, given the small population that progressed from stage 3a to a later stage of CKD. In addition, the Hawaii population is distinguished by a higher proportion of members of Asian/Pacific Islander origin, precluding the use of a control group from another region. We also limited the post-period to 2008 to have a balanced population with the pre-period.
Proactive population-based nephrologist care requires comprehensive health information technology. Our model of care is an example of its meaningful use to improve patient outcomes, in keeping with the spirit of the Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009 . In addition to generating a list of patients with CKD, which is an objective in the menu set of the final regulation, we used health information technology to risk stratify the population, communicate with primary care physicians, and review and record complete clinical information . Our model of care provides additional evidence supporting the federal government’s investment in health information technology as a lever for improving health care quality and efficiency.
However, health information technology alone is insufficient to create change of the magnitude we observed. It is important to note that organization-wide goals and financial incentives are aligned throughout Kaiser Permanente, as an example of an accountable care organization, to provide efficient and effective care and to consider the larger health trajectory of the patient; neither nephrologists nor primary care physicians are penalized or rewarded for shifts in the volume of visits.
Risk stratification allows specialists to address all CKD patients regardless of referral status. This approach can potentially be applied to other chronic conditions in which at least one key metric related to quality of care is available. For instance, pain management specialists might use the number of dispensed opiate prescriptions to identify chronic pain patients with unmet needs, and cardiologists could use the ejection fraction to risk stratify the population of patients with congestive heart failure. Future research is needed to confirm this.
Future research is also needed to evaluate the cost-effectiveness of this approach. We estimated that approximately $8 million in RRT costs were avoided between 2005 and 2008 by the reduced progression to ESRD but did not take into account any other factors. The reduced progression from stage 3a to stage 3b may have no effect on RRT rates or mortality.
Proactive, population-based nephrologist oversight was associated with a statistically significant decrease in progression. In accountable care settings with enabling comprehensive health information technology and aligned incentives, risk stratification and targeted proactive intervention can achieve population-level care improvements in chronic kidney disease. In the face of expanding demand for care under U.S. health care reform, our model provides evidence that health information technology can help leverage existing resources to provide better care for more people.
Jenni Green provided editing assistance.
- Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F, Levey AS: Prevalence of chronic kidney disease in the United States. JAMA. 2007, 298: 2038-2047. 10.1001/jama.298.17.2038.View ArticlePubMedGoogle Scholar
- United States Renal Data System: USRDS 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. 2011, Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney DiseaseGoogle Scholar
- Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J: A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009, 150: 604-612.View ArticlePubMedPubMed CentralGoogle Scholar
- Orlando LA, Owen WF, Matchar DB: Relationship between nephrologist care and progression of chronic kidney disease. N C Med J. 2007, 68: 9-16.PubMedGoogle Scholar
- Martinez-Ramirez HR, Jalomo-Martinez B, Cortes-Sanabria L, Rojas-Campos E, Barragan G, Alfaro G, Cueto-Manzano AM: Renal function preservation in type 2 diabetes mellitus patients with early nephropathy: a comparative prospective cohort study between primary health care doctors and a nephrologist. Am J Kidney Dis. 2006, 47: 78-87. 10.1053/j.ajkd.2005.09.015.View ArticlePubMedGoogle Scholar
- Black C, Sharma P, Scotland G, McCullough K, McGurn D, Robertson L, Fluck N, MacLeod A, McNamee P, Prescott G, Smith C: Early referral strategies for management of people with markers of renal disease: a systematic review of the evidence of clinical effectiveness, cost-effectiveness and economic analysis. Health Technol Assess. 2010, 14: 1-184.View ArticlePubMedGoogle Scholar
- United States Renal Data System: USRDS 2008 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. 2008, Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney DiseaseGoogle Scholar
- Lee BJ, Forbes K: The role of specialists in managing the health of populations with chronic illness: the example of chronic kidney disease. BMJ. 2009, 339: b2395-10.1136/bmj.b2395.View ArticlePubMedGoogle Scholar
- Crosson FJ, Tollen LA: Introduction and vision. Partners in Health: How Physicians and Hospitals Can Be Accountable Together. Edited by: Crosson FJ, Tollen LA. 2010, San Francisco: Jossey-BassGoogle Scholar
- Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, De Zeeuw D, Hostetter TH, Lameire N, Eknoyan G: Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005, 67: 2089-2100. 10.1111/j.1523-1755.2005.00365.x.View ArticlePubMedGoogle Scholar
- Landray MJ, Emberson JR, Blackwell L, Dasgupta T, Zakeri R, Morgan MD, Ferro CJ, Vickery S, Ayrton P, Nair D, Dalton RN, Lamb EJ, Baigent C, Townend JN, Wheeler DC: Prediction of ESRD and death among people with CKD: the Chronic Renal Impairment in Birmingham (CRIB) prospective cohort study. Am J Kidney Dis. 2010, 56: 1082-1094. 10.1053/j.ajkd.2010.07.016.View ArticlePubMedPubMed CentralGoogle Scholar
- Hallan SI, Ritz E, Lydersen S, Romundstad S, Kvenild K, Orth SR: Combining GFR and albuminuria to classify CKD improves prediction of ESRD. J Am Soc Nephrol. 2009, 20: 1069-1077. 10.1681/ASN.2008070730.View ArticlePubMedPubMed CentralGoogle Scholar
- Yang XL, So WY, Kong AP, Clarke P, Ho CS, Lam CW, Ng MH, Lyu RR, Yin DD, Chow CC, Cockram CS, Tong PC, Chan JC: End-stage renal disease risk equations for Hong Kong Chinese patients with type 2 diabetes: Hong Kong Diabetes Registry. Diabetologia. 2006, 49: 2299-2308. 10.1007/s00125-006-0376-3.View ArticlePubMedGoogle Scholar
- Keane WF, Zhang Z, Lyle PA, Cooper ME, de Zeeuw D, Grunfeld JP, Lash JP, McGill JB, Mitch WE, Remuzzi G, Shahinfar S, Snapinn SM, Toto R, Brenner BM: Risk scores for predicting outcomes in patients with type 2 diabetes and nephropathy: the RENAAL study. Clin J Am Soc Nephrol. 2006, 1: 761-767. 10.2215/CJN.01381005.View ArticlePubMedGoogle Scholar
- Critical Appraisal Intensive & Evidence-based Clinical Guideline Development Project to Help Improve Care & Referral for Patients Suffering from Chronic Kidney Disease (CKD). http://www.delfini.org/Showcase_Project_NephrologyCPG.htm.
- Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D: A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999, 130: 461-470.View ArticlePubMedGoogle Scholar
- K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002, 39: S1-S266.Google Scholar
- Chen SC, Chang JM, Chou MC, Lin MY, Chen JH, Sun JH, Guh JY, Hwang SJ, Chen HC: Slowing renal function decline in chronic kidney disease patients after nephrology referral. Nephrology. 2008, 13: 730-736. 10.1111/j.1440-1797.2008.01023.x.View ArticlePubMedGoogle Scholar
- Jones C, Roderick P, Harris S, Rogerson M: An evaluation of a shared primary and secondary care nephrology service for managing patients with moderate to advanced CKD. Am J Kidney Dis. 2006, 47: 103-114. 10.1053/j.ajkd.2005.09.020.View ArticlePubMedGoogle Scholar
- Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC, Sowers JR: Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. 1999, 100: 1134-1146. 10.1161/01.CIR.100.10.1134.View ArticlePubMedGoogle Scholar
- Levey AS, Astor BC, Stevens LA, Coresh J: Chronic kidney disease, diabetes, and hypertension: what's in a name?. Kidney Int. 2010, 78: 19-22. 10.1038/ki.2010.115.View ArticlePubMedGoogle Scholar
- Feldstein AC, Perrin NA, Unitan R, Rosales AG, Nichols GA, Smith DH, Schneider J, Davino CM, Zhou YY, Lee NL: Effect of a patient panel-support tool on care delivery. Am J Manag Care. 2010, 16: e256-e266.PubMedGoogle Scholar
- Zhou YY, Unitan R, Wang JJ, Garrido T, Chin HL, Turley MC, Radler L: Improving population care with an integrated electronic panel support tool. Popul Health Manag. 2010, 14: 3-9.View ArticlePubMedGoogle Scholar
- Brown WW, Peters RM, Ohmit SE, Keane WF, Collins A, Chen SC, King K, Klag MJ, Molony DA, Flack JM: Early detection of kidney disease in community settings: the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2003, 42: 22-35. 10.1016/S0272-6386(03)00405-0.View ArticlePubMedGoogle Scholar
- Giannelli SV, Graf CE, Herrmann FR, Michel JP, Patel KV, Pizzarelli F, Ferrucci L, Guralnik J: Natural history of older adults with impaired kidney function: the InCHIANTI study. Rejuvenation Res. 2011, 14: 513-523. 10.1089/rej.2011.1179.View ArticlePubMedPubMed CentralGoogle Scholar
- Altemtam N, Russell J, El Nahas M: A study of the natural history of diabetic kidney disease (DKD). Nephrol Dial Transplant. 2012, 27 (5): 1847-1854. 10.1093/ndt/gfr561.View ArticlePubMedGoogle Scholar
- Yamashita T, Yoshida T, Ogawa T, Tsuchiya K, Nitta K: Clinical outcomes in patients with chronic kidney disease: a 5-year retrospective cohort study at a University Hospital in Japan. Clin Exp Nephrol. 2011, 15: 831-840. 10.1007/s10157-011-0501-6.View ArticlePubMedGoogle Scholar
- Blumenthal D: Launching HITECH. N Engl J Med. 2010, 362: 382-385. 10.1056/NEJMp0912825.View ArticlePubMedGoogle Scholar
- Blumenthal D, Tavenner M: The "Meaningful Use" Regulation for Electronic Health Records. N Engl J Med. 2010, 363: 501-504. 10.1056/NEJMp1006114.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://0-www.biomedcentral.com.brum.beds.ac.uk/1472-6963/12/252/prepub
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