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Table 1 Adoption times for medicines adopted in Australia, by drug class

From: Nation-scale adoption of new medicines by doctors: an application of the Bass diffusion model

Medicine (INN), by Anatomical main group (ATC)

Month of the first subsidised prescription

Maximum monthly prescriptions (per 100,000 Australians)

p/q ratio from Bass diffusion model

Model fit for Bass diffusion model (R2)

Modelled Adoption time (years)

Alimentary tract and metabolism

Esomeprazole

Mar 2002

2755

5.87×10-1

0.990

8.67

Clarithromycin*

Dec 1998

384

1.50×109

0.865

14.08

Granisetron

Dec 2003

45

3.30×10-2

0.986

5.58

Ursodeoxycholic acid*

Jun 2000

13

8.50×109

0.948

9.75

Balsalazide

Mar 2005

9

1.08×10-1

0.995

4.58

Insulin lispro

Jun 1996

30

4.52×10-1

0.973

6.75

Insulin glargine

May 2006

113

5.57×10-1

0.961

5.50

Glimepiride

Jun 2000

263

3.40×10-2

0.981

2.42

Rosiglitazone

Jun 2003

228

3.40×10-2

0.969

4.17

Pioglitazone

Jun 2003

226

1.21×10-1

0.912

8.83

Acarbose

Jun 1997

38

6.20×10-2

0.991

2.25

Blood and blood forming organs

Enoxaparin

Nov 1993

123

4.00×10-3

0.990

14.42

Clopidogrel

Apr 1999

1327

2.69×10-1

0.994

11.33

Ticlopidine

Nov 1992

15

1.90×10-2

0.976

6.08

Dipyridamole

Mar 1999

74

1.10×10-2

0.962

1.17

Abciximab

Dec 1995

2

5.00×10-2

0.965

5.83

Tirofiban

Jun 1999

1

3.37×10-1

0.979

4.92

Cardiovascular system

Nicorandil

Sep 1997

110

6.97×10-1

0.979

13.58

Eplerenone

Sep 2005

5

1.19×10-1

0.986

5.00

Bisoprolol

Mar 2002

211

2.80×10-2

0.983

9.08

Carvedilol

Dec 1997

256

1.39×10-1

0.991

9.50

Amlodipine*

Mar 1993

1378

1.86×109

0.863

12.92

Lisinopril

Apr 1992

744

1.79×10-1

0.992

4.92

Perindopril

Mar 1992

3174

4.60×10-2

0.991

18.08

Ramipril

Apr 1992

1550

5.60×10-2

0.976

14.83

Quinapril

Sep 1992

453

8.00×10-3

0.953

7.25

Fosinopril*

Apr 1992

491

2.45

0.933

8.75

Trandolapril

Nov 1994

424

6.90×10-2

0.980

4.58

Eprosartan

Apr 1999

98

3.50×10-2

0.983

6.25

Irbesartan

Dec 1997

3333

6.51×10-1

0.992

9.33

Candesartan

Sep 1998

1640

1.02×10-1

0.995

11.83

Telmisartan

Jun 1999

1535

1.07×10-1

0.969

12.25

Pravastatin

Jan 1993

895

9.20×10-2

0.991

10.58

Fluvastatin

Sep 1995

223

2.80×10-2

0.952

1.83

Atorvastatin

Sep 1997

5096

8.67×10-1

0.987

13.42

Rosuvastatin

Jun 2006

1967

3.60×10-2

0.990

3.83

Fenofibrate

Mar 2004

250

3.00×10-2

0.991

6.00

Ezetimibe*

Mar 2004

419

1.30

0.974

6.17

Dermatologicals

Fluconazole*

May 1992

11

2.83×108

0.909

23.33

Imiquimod

Nov 2005

14

1.33×10-1

0.952

1.42

Fluticasone

Mar 1995

552

1.20×10-2

0.979

5.17

Tacrolimus

Mar 2003

6

2.46×10-1

0.967

9.92

Finasteride*

Jun 1995

25

1.71

0.838

18.50

Genito urinary system and sex hormones

Raloxifene

May 1999

153

4.80×10-2

0.994

2.75

Alprostadil

Jun 1995

64

2.00×10-3

0.989

2.42

Antiinfectives for systemic use

Roxithromycin

Jun 1992

1244

7.50×10-1

0.972

5.33

Azithromycin

Jan 1995

47

1.26×10-1

0.916

17.17

Itraconazole*

Jun 1997

3

1.94×108

0.955

8.75

Famciclovir*

Jun 1995

64

4.79×1011

0.902

17.08

Valaciclovir

Mar 1996

160

1.54×10-1

0.997

13.50

Antineoplastic and immunomodulating agents

Temozolomide

Sep 1999

5

5.98×10-1

0.910

12.33

Gemcitabine

Dec 1995

9

2.08×10-1

0.974

8.50

Capecitabine*

Jun 1999

9

2.22

0.928

8.58

Vinorelbine

Jun 1998

1

4.10×10-2

0.980

2.00

Paclitaxel

May 1994

9

2.96×10-1

0.942

17.92

Docetaxel

Mar 1996

9

5.39×10-1

0.850

19.25

Oxaliplatin

Jun 2001

8

4.46×10-1

0.971

5.00

Rituximab

Sep 1998

18

1.85×10-1

0.983

10.50

Imatinib

Jul 2001

9

1.70×10-2

0.976

1.92

Irinotecan

Dec 1999

5

8.00×10-3

0.865

1.08

Nilutamide

Dec 1996

2

3.10×10-2

0.977

1.92

Anastrozole

Mar 1997

89

2.00×10-3

0.982

12.42

Letrozole

Dec 1997

51

6.00×10-2

0.928

15.42

Exemestane

Aug 2000

9

2.03×10-1

0.921

11.67

Interferon beta1a*

Sep 1998

16

2.87×107

0.977

9.75

Interferon alfa2a

Jul 1992

1

1.20×10-2

0.900

8.33

Leflunomide*

Sep 1999

78

2.87×109

0.948

12.58

Etanercept

Mar 2003

27

8.60×10-2

0.989

7.58

Adalimumab

Dec 2003

36

1.90×10-2

0.980

6.92

Musculo-skeletal system

Rofecoxib

Jun 2000

1281

1.40×10-2

0.963

1.75

Celecoxib

Jun 1999

1806

2.00×10-3

0.981

1.58

Alendronic acid

Jun 1996

955

9.00×10-3

0.991

8.25

Risedronic acid

Sep 2000

583

6.20×10-2

0.993

8.42

Nervous system

Fentanyl

Mar 1999

203

6.00×10-3

0.910

12.25

Tramadol

Apr 1999

954

1.10×10-2

0.962

4.33

Oxcarbazepine*

May 1999

6

3.84

0.955

8.42

Lamotrigine

Jul 1994

146

7.11×10-1

0.984

17.17

Topiramate

Mar 1997

87

1.80×10-1

0.921

18.25

Gabapentin

Jul 1994

75

8.10×10-2

0.974

14.67

Flupentixol

Mar 1994

8

4.99×10-1

0.988

5.08

Zuclopenthixol

Jun 1996

10

1.21×10-1

0.956

6.83

Olanzapine*

Mar 1997

391

1.87

0.961

11.08

Quetiapine

Jun 2000

262

5.90×10-2

0.950

11.75

Amisulpride

Mar 2002

36

8.60×10-2

0.952

2.42

Risperidone

Sep 1994

268

9.10×10-2

0.927

17.67

Aripiprazole*

Dec 2003

47

5.50

0.975

5.50

Citalopram

Sep 1997

757

6.30×10-2

0.994

5.50

Paroxetine

Mar 1994

581

1.33×10-1

0.996

5.92

Sertraline

Mar 1994

1181

3.55×10-1

0.985

9.67

Fluvoxamine

Mar 1997

183

2.21×10-1

0.997

8.00

Venlafaxine

Mar 1996

1167

1.15×10-1

0.990

12.83

Methylphenidate

Feb 2005

156

6.50×10-2

0.992

3.92

Donepezil

Apr 1999

102

3.83×10-1

0.955

6.75

Rivastigmine

Mar 2000

13

1.00×10-3

0.946

1.42

Galantamine

Jun 2001

47

1.10×10-1

0.996

4.92

Acamprosate

Jun 1999

12

2.40×10-2

0.944

0.92

Riluzole*

Feb 2003

3

3.49×105

0.975

6.08

Respiratory system

Nedocromil

Nov 1994

115

5.00×10-2

0.986

2.08

Salmeterol

Sep 1994

1362

1.10×10-2

0.944

10.00

Formoterol

Dec 1996

644

8.90×10-2

0.948

16.75

Tiotropium*

Sep 2002

748

3.537

0.969

8.50

Montelukast*

Sep 2002

78

4.82

0.969

7.08

Sensory organs

Latanoprost*

Dec 1997

689

2.99×109

0.923

7.92

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BMC Health Services Research

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