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Table 1 Determinants of Markov states in the literature

From: Improving the evidence base of Markov models used to estimate the costs of scaling up antiretroviral programmes in resource-limited settings

Markov states defined by:

Bachmann 2006

Badri et al 2006

Cleary et al 2006; 2008

Goldie et al 2006

Marseille et al 2006

Vijayaraghavan et al 2007

Baseline CD4 stratum

 

<200, 200-350, >350

<50, 50-200

<50; 50-200; 200-500; >500

  

Current CD4 stratum

<200, 200-350

<200, 200-350, >350

 

<50; 50-200; 200-500; >500

  

Baseline viral load stratum

   

>100,000; 30,001-100,000; 10,001-30,000; 3,001-10,000; 501-3,000; 0-500

  

Current viral load stratum

   

>100,000; 30,001-100,000; 10,001-30,000; 3,001-10,000; 501-3,000; 0-500

 

Suppressed; unsuppressed

Time on ART

  

0-3; 3-6; 6-12; 12-24; 24-36; >36 months

   

First or second line ARV regimen

 

Yes

Yes

Yes

Yes

Yes

Disease staging or opportunistic infections

Tuberculosis, other opportunistic infection, no opportunistic infection

No-AIDS/ AIDS

 

Severe bacterial infection; severe fungal infection; severe malaria; tuberculosis; isosporiasis; cerebral toxoplasmosis; nontuberculous mycobacteriosis; other severe opportunistic infection; mild bacterial infection; mild fungal infection; other mild infection

WHO Stages (1, 2, 3, 4)

AIDS

Adverse events

     

Toxicity; no toxicity